Childhood sarcoidosis in the middle Anatolia of Turkey

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dc.contributor.authorHangul, Melih
dc.contributor.authorKose, Mehmet
dc.contributor.authorPekcan, Sevgi
dc.contributor.authorErsoy, Ali
dc.contributor.authorUnal, Gokcen
dc.contributor.authorCaglar, Hanife Tugce
dc.date.accessioned2024-02-23T13:03:31Z
dc.date.available2024-02-23T13:03:31Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractObjectiveThis retrospective study aimed to describe the clinical and radiological features, diagnostic methods, laboratory findings, organ involvement, and treatment strategies of 22 patients who followed up with late-onset childhood sarcoidosis and compare them with the literature. Material and MethodThis retrospective multicenter study reviewed the medical records of 22 children with sarcoidosis who applied to the Pediatric pulmonology department of Erciyes University Faculty of Medicine and Necmettin Erbakan Faculty of Medicine in 2012 and 2022. ResultsThe mean age of the patients at the time of diagnosis was 13.1/year (interquartile range [IQR]1:6.3-[IQR]3:15.7). The most common first presenting symptom was cough 40.9% (n = 9), weight loss 31.8% (n = 7), and dyspnea 22.7% (n = 5). There were elevated levels of C-reactive protein (CRP; 59%), angiotensin-converting enzyme (ACE; 54.5%), erythrocyte sedimentation rate (ESR; 54.5%), and immunoglobulin G (IgG; 54.5%). Twenty patients (90%) received systemic steroid treatment. Eighteen (81.8%) of these patients responded positively to treatment. Two patients had a recurrence. ConclusionThe incidence of sarcoidosis in children in Turkey is currently unknown. However, a regional average of 2.2 cases per year has been documented for the first time. Contrary to previous studies, a significant prevalence of consanguineous marriage was observed in our study. While constitutional symptoms were most common in other studies, the cough was the most common symptom in our study. To our knowledge, this is one of the Turkish studies with the highest number of sarcoidosis in children and one of the few European studies on sarcoidosis in children.en_US
dc.identifier.doi10.1002/ppul.26564
dc.identifier.endpage2627en_US
dc.identifier.issn8755-6863
dc.identifier.issn1099-0496
dc.identifier.issue9en_US
dc.identifier.pmid37341617en_US
dc.identifier.scopus2-s2.0-85162968777en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2619en_US
dc.identifier.urihttps://doi.org/10.1002/ppul.26564
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10655
dc.identifier.volume58en_US
dc.identifier.wosWOS:001009842600001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Pulmonologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildhooden_US
dc.subjectNoncaseating Granulomaen_US
dc.subjectSarcoidosisen_US
dc.titleChildhood sarcoidosis in the middle Anatolia of Turkeyen_US
dc.typeArticleen_US

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