Association Between Nonalcoholic Fatty Liver Disease and Cardiovascular Risk in Obese Children and Adolescents

Basit Öğe Kaydı
dc.contributor.authorAlp, Hayrullah
dc.contributor.authorKaraarslan, Sevim
dc.contributor.authorEklioglu, Beray Selver
dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorAltin, Hakan
dc.contributor.authorBaysal, Tamer
dc.date.accessioned2024-02-23T14:02:27Z
dc.date.available2024-02-23T14:02:27Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractBackground: The recent rise in the prevalence of obesity likely explains nonalcoholic fatty liver disease (NAFLD) epidemic worldwide. We evaluated cardiac functions, cardiovascular risk, and associated parameters with grades of NAFLD in obese children. Methods: Four hundred obese children were enrolled in the study. Obese children with NAFLD were classified in 2 subgroups according to ultrasonographic visualizing. Ninety-three obese children with NAFLD (mean age 11.73 +/- 2.72 years in group 2 and 12.69 +/- 2.61 years in group 3) were compared with 307 age- and sex-matched non-NAFLD obese children and 150 control subjects. Laboratory parameters were measured during the fasting state. Pulsed and tissue Doppler echocardiography were performed. Intima-media (IMT) and epicardial adipose tissue (EAT) thicknesses were measured. Results: NAFLD groups had a significantly higher body mass index (29.15 +/- 3.42 and 30.46 +/- 4.60; P < 0.001), total adipose tissue mass (37.95 +/- 4.46% and 46.57 +/- 6.45%; P < 0.001), higher insulin, alanine aminotransferase, and aspartate aminotransferase levels. Increased end-systolic thickness of the interventricular septum (P < 0.001), larger left ventricular mass (P < 0.003) and index (P < 0.003) were found in NAFLD groups. Children with NAFLD had higher Tei index values. Also, carotid artery IMT and EAT thickness were significantly higher in obese children. Waist and hip circumference, total cholesterol level, total adipose tissue mass, and interventricular septum were statistically different in NAFLD groups. Conclusions: Children with NAFLD had mildly altered left and right ventricular functions and all obese children had increased IMT and EAT thickness. Also, grade of liver steatosis was positively correlated with total adipose tissue mass and interventricular septum systolic thickness.en_US
dc.identifier.doi10.1016/j.cjca.2012.07.846
dc.identifier.endpage1125en_US
dc.identifier.issn0828-282X
dc.identifier.issn1916-7075
dc.identifier.issue9en_US
dc.identifier.pmid23040432en_US
dc.identifier.scopus2-s2.0-84882893767en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1118en_US
dc.identifier.urihttps://doi.org/10.1016/j.cjca.2012.07.846
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11719
dc.identifier.volume29en_US
dc.identifier.wosWOS:000323483200017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofCanadian Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleAssociation Between Nonalcoholic Fatty Liver Disease and Cardiovascular Risk in Obese Children and Adolescentsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu