A case of severe vasculitis after FLOT chemotherapy in a patient with metastatic gastric cancer who received multiple line chemotherapy

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dc.contributor.authorHendem, Engin
dc.contributor.authorKorkmaz, Mustafa
dc.contributor.authorUkrakli, Muzaffer
dc.contributor.authorEryilmaz, Melek Karakurt
dc.contributor.authorKaraagac, Mustafa
dc.contributor.authorAraz, Murat
dc.contributor.authorArtac, Mehmet
dc.date.accessioned2024-02-23T14:27:02Z
dc.date.available2024-02-23T14:27:02Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractIntroduction Leukocytoclastic vasculitis is a histopathological term describing vasculitis in which the inflammatory infiltrate in small vessels consists of neutrophils. Although FLOT is given perioperatively in locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma, it has recently become a popular treatment option for metastatic cancers. In this case report, we present a case of FLOT-induced LCV. Case Report We present a 52-year-old patient with metastatic gastric adenocarcinoma treated with FLOT. The patient developed necrotizing vasculitis in the lower extremity after 5 cycles of FLOT. Management & Outcome After discontinuation of the FLOT regimen, the necrotizing morbid LCV gradually regressed with steroid therapy. Discussion To the best of our knowledge, our case is the first case of LCV that developed after FLOT chemotherapy. The clinical appearance of the patient, occurrence after chemotherapy, erythematous rash developing on bilateral lower extremities, and palpable purpuric vasculitis made us suspect. We found a potential relationship between FLOT and vasculitis according to the Naranjo scale (score 4 + ).en_US
dc.identifier.doi10.1177/10781552221074046
dc.identifier.endpage1225en_US
dc.identifier.issn1078-1552
dc.identifier.issn1477-092X
dc.identifier.issue5en_US
dc.identifier.pmid35044279en_US
dc.identifier.scopus2-s2.0-85123492342en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1222en_US
dc.identifier.urihttps://doi.org/10.1177/10781552221074046
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14430
dc.identifier.volume28en_US
dc.identifier.wosWOS:000749319700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal Of Oncology Pharmacy Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrug-Related Side Effectsen_US
dc.subjectGastric Canceren_US
dc.subjectFloten_US
dc.subjectLeukocytoclastic Vasculitisen_US
dc.titleA case of severe vasculitis after FLOT chemotherapy in a patient with metastatic gastric cancer who received multiple line chemotherapyen_US
dc.typeArticleen_US

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