Effects of Silybum marianum Extract on High-Fat Diet Induced Metabolic Disorders in Rats

Basit Öğe Kaydı
dc.contributor.authorSayin, Fatma Kubra
dc.contributor.authorBuyukbas, Sadik
dc.contributor.authorBasarali, M. Kemal
dc.contributor.authorAlp, Harun
dc.contributor.authorToy, Hatice
dc.contributor.authorUgurcu, Veli
dc.date.accessioned2024-02-23T14:29:52Z
dc.date.available2024-02-23T14:29:52Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractSilybum marianum extract (SME) has been used for centuries as a natural remedy for diseases of liver and biliary tract. Lately, it has been promoted as a nutritional supplement for beneficial effects on some risk factors of diabetes and hyperlipidemia. In this study we aimed to determine the effects of SME on high-fat diet (HFD) induced metabolic disorders. Male Sprague Dawley rats were fed HFD for 11 weeks to induce obesity. SME was given to animals for two different durations, for 11 weeks or for 7 weeks. The results showed significant increase in plasma transaminases, total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), leptin, high sensitive C-reactive protein (hsCRP), glucose and insulin along with significant increase in body mass index (BMI) and liver weights in rats fed the HFD diet compared to rats fed with standard rat diet. SME supplementation for different durations raised improvement in the HFD-induced metabolic disorders such as insulin resistance, hyperlipidemia and hepatopathy at different degrees. Our study concludes that SME can be well considered as an effective supplement to improve insulin and leptin sensitivity and hyperlipidemia and to suppress body weight gain.en_US
dc.description.sponsorshipSelcuk University Scientific Investigation Programen_US
dc.description.sponsorshipThis research was supported by Selcuk University Scientific Investigation Program.en_US
dc.identifier.doi10.1515/pjfns-2015-0014
dc.identifier.endpage49en_US
dc.identifier.issn1230-0322
dc.identifier.issn2083-6007
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84958191432en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.1515/pjfns-2015-0014
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14897
dc.identifier.volume66en_US
dc.identifier.wosWOS:000369320200007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInst Animal Reproduction & Food Research Polish Acad Sciences Olsztynen_US
dc.relation.ispartofPolish Journal Of Food And Nutrition Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSilybum Marianumen_US
dc.subjectCholesterolen_US
dc.subjectInsulinen_US
dc.subjectLeptinen_US
dc.subjectHigh-Fat Dieten_US
dc.titleEffects of Silybum marianum Extract on High-Fat Diet Induced Metabolic Disorders in Ratsen_US
dc.typeArticleen_US

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