Polyethylenimine-functionalized microcryogels for controlled release of diclofenac sodium

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dc.contributor.authorCetin, Kemal
dc.contributor.authorDenizli, Adil
dc.date.accessioned2024-02-23T14:13:40Z
dc.date.available2024-02-23T14:13:40Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractVarious changes in the environment can occur as drug delivery systems travel to the targeted area. Therefore, it is an important aspect to consider the effects of environmental changes such as pH and temperature on the release in the development of drug delivery systems. Microcryogels having predefined shape and size were fabricated as drug delivery systems and loaded with diclofenac sodium, a non-steroidal anti-inflammatory drug. Physicochemical, structural, and morphological properties of microcryogels were investigated by swelling, pore volume and porosity tests, infrared spectroscopy, and field emission scanning electron microscopy. Effects of medium pH on drug release were examined at release media with the pH 2.0 as simulated gastric juice, pH 7.4 as the simulated intestinal fluid/intravenous solution, pH 6.0 as a simulated medium during a normal wound healing, and pH 9.0 as a simulated medium for infected wounds. Effects of temperature on drug release were also analyzed at 37 degrees C as normal body temperature and 42 degrees C as inflammatory temperature. The obtained results showed that drug release was too low in acidic environment than those observed at higher pH values. Moreover, the release rates were higher at inflammatory temperature compared with the ones at normal body temperature.en_US
dc.identifier.doi10.1016/j.reactfunctpolym.2021.105125
dc.identifier.issn1381-5148
dc.identifier.issn1873-166X
dc.identifier.scopus2-s2.0-85120429023en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.reactfunctpolym.2021.105125
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12528
dc.identifier.volume170en_US
dc.identifier.wosWOS:000786698000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofReactive & Functional Polymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCryogelsen_US
dc.subjectDiclofenac Sodiumen_US
dc.subjectMicrocryogelsen_US
dc.subjectPh Changeen_US
dc.subjectPolyethylenimineen_US
dc.titlePolyethylenimine-functionalized microcryogels for controlled release of diclofenac sodiumen_US
dc.typeArticleen_US

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