Hyperconnecitivity between dorsal attention and frontoparietal networks predicts treatment response in obsessive-compulsive disorder

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dc.contributor.authorBakay, Hasan
dc.contributor.authorUlasoglu-Yildiz, Cigdem
dc.contributor.authorKurt, Elif
dc.contributor.authorDemiralp, Tamer
dc.contributor.authorTukel, Rasit
dc.date.accessioned2024-02-23T14:13:38Z
dc.date.available2024-02-23T14:13:38Z
dc.date.issued2024
dc.departmentNEÜen_US
dc.description.abstractObsessive-compulsive disorder (OCD) presented with repetitive obsessions and/or compulsions were associated with disrupted resting-state functional connectivity (rs-FC). To investigate the pharmacological treatment effect on rs-FC changes in OCD patients we conducted the seed-to-voxel FC analyses using dorsal attention network (DAN), default mode network (DMN), salience network (SN) and frontoparietal network (FPN) and basal ganglia seeds. Twenty-two healthy subjects and twenty-four unmedicated OCD patients underwent resting-state functional magnetic resonance imaging. Patients were rescanned after 12 weeks of escitalopram treatment. We found increased FC both within the DAN and between the DAN and the FPN which was ameliorated after medication and correlated significantly with the clinical improvement in obsession scores. We also observed an anti-correlation between the left caudate and the supplementary motor area in unmedicated OCD patients which also normalized with treatment. Results further showed treatment related normalization of orbitofrontal cortex hyperconnectivity with DMN and hypoconnectivity with DAN whereas aberrant FC between the SN and visual areas appears to be a medication effect. We suggest that DAN to FPN hyperconnectivity which is positively correlated with clinical improvement in obsession scores at pre-treatment stage in present study has a potential for being a neuroimaging marker to predict the treatment response in OCD.en_US
dc.description.sponsorshipIstanbul University Scientific Research Projects Unit [20349]en_US
dc.description.sponsorshipFunding This study was supported by Istanbul University Scientific Research Projects Unit (Project Number: 20349) .en_US
dc.identifier.doi10.1016/j.pscychresns.2023.111763
dc.identifier.issn0925-4927
dc.identifier.issn1872-7506
dc.identifier.pmid38056116en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.pscychresns.2023.111763
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12513
dc.identifier.volume337en_US
dc.identifier.wosWOS:001135238800001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Research-Neuroimagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectResting State Functional Connectivityen_US
dc.subjectObsessive-Compulsive Disorderen_US
dc.subjectDorsal Attention Networken_US
dc.subjectDefault Mode Networken_US
dc.subjectSalience Networken_US
dc.subjectFrontoparietal Networken_US
dc.subjectTreatment Effecten_US
dc.titleHyperconnecitivity between dorsal attention and frontoparietal networks predicts treatment response in obsessive-compulsive disorderen_US
dc.typeArticleen_US

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