Liporotein-associated phospholipase-A2 can be a diagnostic marker in the early stage diagnosis of acute mesenteric ischemia

Basit Öğe Kaydı
dc.contributor.authorAcar, Tarik
dc.contributor.authorKocak, Sedat
dc.contributor.authorCander, Basar
dc.contributor.authorErgin, Mehmet
dc.contributor.authorDikmetas, Cesareddin
dc.date.accessioned2024-02-23T14:37:22Z
dc.date.available2024-02-23T14:37:22Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: The purpose of this experimental study was to investigate the role of lipoprotein-associated phospholipase-A(2) (Lp-PLA(2)) in the diagnosis of acute mesenteric ischemia (AMI) in the early stage. Materials and methods: Twenty-seven New Zealand rabbits were randomly divided into 3 groups in this study. Blood specimens were obtained from the groups at hours 0, 1, 3, and 6. Using the blood samples drawn from all groups, Lp-PLA(2) and C-reactive protein (CRP) parameters were investigated. Results: There was a significant rise in the levels of both Lp-PLA(2) and CRP starting at hour 1 (P < 0.05) (hour 1; Lp-PLA(2), P = 0.003) in the ischemia group. In the sham group, the levels of Lp-PLA(2) and CRP started to rise at hour 3 (P < 0.05) (hour 3; Lp-PLA(2), P = 0.011). At hour 6 of ischemia, the area under the ROC curve was 100%, and the cut-off value of 63.91 ng/mL revealed a sensitivity of 88% and a specificity of 100% for Lp-PLA(2). Conclusion: These findings showed the role of serum Lp-PLA(2) and CRP levels in the early diagnosis of AMI. Thus, further studies are needed to describe the role of Lp-PLA(2) in the early diagnosis of AMI.en_US
dc.identifier.doi10.3906/sag-1412-29
dc.identifier.endpage125en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.pmid27511344en_US
dc.identifier.scopus2-s2.0-84953741840en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1412-29
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16072
dc.identifier.volume46en_US
dc.identifier.wosWOS:000368558600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Mesenteric Ischemiaen_US
dc.subjectLipoprotein-Associated Phospholipase-A(2)en_US
dc.subjectC-Reactive Proteinen_US
dc.subjectExperimental Studyen_US
dc.titleLiporotein-associated phospholipase-A2 can be a diagnostic marker in the early stage diagnosis of acute mesenteric ischemiaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu