An association between immune status and chest CT scores in COVID-19 patients

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dc.contributor.authorColkesen, Fatih
dc.contributor.authorPoyraz, Necdet
dc.contributor.authorArslan, Sevket
dc.contributor.authorYilmaz, Pinar Diydem
dc.contributor.authorKurt, Esma Kepenek
dc.contributor.authorKorkmaz, Celalettin
dc.contributor.authorYildiz, Eray
dc.date.accessioned2024-02-23T14:24:15Z
dc.date.available2024-02-23T14:24:15Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground The characteristic features of the immune responses of COVID-19 patients and how they reflect lung involvement have not been clearly elucidated. Aim The aim of this study was to examine the immune status and the correlations thereof with chest CT scores and lung involvement of patients with COVID-19. Methods In this retrospective and single-center study, 72 patients with laboratory-confirmed COVID-19 were recruited. The counts of peripheral lymphocyte subsets (CD3(+) T cells, CD4(+) T cells, CD8(+) T cells, CD19(+) B cells and CD16(+) 56(+) NK cells) and those of serum immunoglobulins (IgA, IgG, IgM) were measured and their associations with chest CT scores analysed. Results The proportions of lymphopenia in patients with extensive lung involvement were twice that in the general study population. In the severe disease group, the levels of total lymphocytes, T cells, B cells, NK cells; and serum IgA levels, were significantly lower than in the mild disease group (all P < .05). We found that the numbers of lymphocyte subsets and the IgA level negatively correlated with the chest CT scores. On multivariate regression analysis, pretreatment decreases in total lymphocytes, CD3(+) T cells, CD4(+) T cells, and CD19(+) B cells, and serum IgA levels, were independent predictors of severe lung involvement. Conclusions The cell numbers of peripheral lymphocyte subsets and the serum IgA level were negatively correlated with the chest CT scores in COVID-19 patients. These parameters tended to independently predict severe lung involvement in such patients.en_US
dc.identifier.doi10.1111/ijcp.14767
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.issue11en_US
dc.identifier.pmid34478612en_US
dc.identifier.scopus2-s2.0-85114703669en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/ijcp.14767
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13870
dc.identifier.volume75en_US
dc.identifier.wosWOS:000695070300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal Of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleAn association between immune status and chest CT scores in COVID-19 patientsen_US
dc.typeArticleen_US

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