Fullerene-based mimics of enhanced acetylcholine detection for the diagnosis of Alzheimer's disease

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dc.contributor.authorSoylemez, Saniye
dc.contributor.authorDolgun, Volkan
dc.contributor.authorOzcubukcu, Salih
dc.date.accessioned2024-02-23T14:13:17Z
dc.date.available2024-02-23T14:13:17Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractThe design of sensitive and cost-effective enzyme-free sensor systems for the effective electrooxidation of acetylcholine (ACh) plays a key role in following up on Alzheimer's disease. We report a fullerenzyme-based catalyst (F-HS) for the electrochemical detection of ACh that mimics enzymatic active sites using multifunc-tional self-assembled nanostructures. As a proof-of-concept, histidine and serine amino acid-based functionali-zation of fullerenzymes was used, along with embedded nickel ions (F-HS-Ni), which tend to coordinate with the nitrogen of the imidazole ring of the histidine moiety. Further, the electrode modifier properties of the resulting material were examined for sensor applications. Enhanced cyclic voltammetry and chronoamperometric mea-surements affirmed that the F-HS-Ni material displayed the most prominent activity for the electrocatalytic oxidation of ACh, allowing an amperometric response in a linear range of ACh concentrations of 20-6000 & mu;M with a low detection limit of 8.01 & mu;M. Furthermore, the platform allows for the detection of ACh with a good rate of recovery in human serum samples, offering a good potential method for the quick detection and diagnosis of Alzheimer's.en_US
dc.description.sponsorshipUNESCO-LOREAL Awards for Women in Science-2021en_US
dc.description.sponsorship& nbsp;Dr. Saniye Soylemez thanks the UNESCO-LOREAL Awards for Women in Science-2021 for financial support.en_US
dc.identifier.doi10.1016/j.microc.2023.109099
dc.identifier.issn0026-265X
dc.identifier.issn1095-9149
dc.identifier.scopus2-s2.0-85165672860en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.microc.2023.109099
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12356
dc.identifier.volume193en_US
dc.identifier.wosWOS:001047503400001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMicrochemical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFullerenol Derivativesen_US
dc.subjectEnzyme Mimicen_US
dc.subjectElectrochemical Sensoren_US
dc.subjectAcetylcholineen_US
dc.subjectAlzheimeren_US
dc.titleFullerene-based mimics of enhanced acetylcholine detection for the diagnosis of Alzheimer's diseaseen_US
dc.typeArticleen_US

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