Effects of topical mitomycin-C on the tracheal epithelia of rabbits following tracheostomy

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dc.contributor.authorCalik, Saniye Goknil
dc.contributor.authorCalik, Mustafa
dc.contributor.authorKasdogan, Zumrut Ela Arslan
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorAribas, Olgun Kadir
dc.contributor.authorEsme, Hidir
dc.date.accessioned2024-02-23T14:37:22Z
dc.date.available2024-02-23T14:37:22Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: We aimed to investigate the topical application of mitomycin-C (MMC) after the conventional tracheostomy in a rabbit model. Materials and methods: Twenty-four male New Zealand White rabbits were randomly divided among 3 equal groups (n: 8). Tracheostomies were performed on 16 subjects. Group 1 which served as a control for all tracheal measurements. After tracheostomy, we applied sterile saline (group 2) or MMC at 0.8 mg/mL (group 3) around the tracheotomy site for 5 min. At the 3rd week after surgery, all tracheas were subjected to morphometric and histopathological examinations, including tracheal lumen diameter (LD), number of capillary vessels (CV), subepithelial tissue thickness (SETT), fibroblasts, and inflammatory cells (IC). Results: There was a statistically significant difference between the two tracheostomy groups themselves and the control group for LD (p = 0.035), CV (p = 0.006), SETT, fibroblasts, and IC (p < 0.001). Histopathological analysis showed the decreased LD, CV, SETT, IC, and fibroblasts compared to MMC with tracheostomy groups. MMC was more effective than saline for LD, CV, SETT, IC, and fibroblasts. Conclusion: Wound healing modulation may prevent scar formation. Fibrosis decreased following tracheostomy in the group treated with MMC. Fibroblasts appear to be key cells mediating these effects.en_US
dc.description.sponsorshipSchool of Medicine Animal Care and Investigational Committeeen_US
dc.description.sponsorshipThis study was approved and funded by the School of Medicine Animal Care and Investigational Committee in our institution.en_US
dc.identifier.doi10.3906/sag-1802-187
dc.identifier.endpage863en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.pmid31655519en_US
dc.identifier.scopus2-s2.0-85105507354en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage857en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1802-187
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16077
dc.identifier.volume51en_US
dc.identifier.wosWOS:000646231300007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTracheostomyen_US
dc.subjectTracheal Epitheliaen_US
dc.subjectRabbitsen_US
dc.subjectMitomycin-C (Mmc)en_US
dc.titleEffects of topical mitomycin-C on the tracheal epithelia of rabbits following tracheostomyen_US
dc.typeArticleen_US

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