The presence of Torque teno virus in chronic obstructive pulmonary disease

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dc.contributor.authorFeyzioglu, Bahadir
dc.contributor.authorTeke, Turgut
dc.contributor.authorOzdemir, Mehmet
dc.contributor.authorKaraibrahimoglu, Adnan
dc.contributor.authorDogan, Metin
dc.contributor.authorYavsan, Mehmet
dc.date.accessioned2024-02-23T14:45:53Z
dc.date.available2024-02-23T14:45:53Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractTorque Teno Virus (TTV) has been identified as transfusion-transmitted virus in humans, initially. Although TTV viremia is extremely common in the general population worldwide, there is no direct causal evidence linking TTV infection to specific clinical manifestations. Our hypothesis was that TTV might play a role in Chronic obstructive pulmonary disease (COPD) by inducing inflammatory mechanisms previously identified. The study was conducted on 57 COPD patients and 39 healthy control groups. COPD patient groups included: the patients (n:20) with exacerbation needed noninvasive ventilation, the patients (n: 19) who received only medical treatment, and the invited patients (n: 18) for outpatient control. Serum samples were collected from patients and voluntary blood donors. TTV DNA quantification was carried out with a real time PCR by the hybridization probe system and viral load was interpreted through the crossing point value. TTV DNA was detected in the majority of both patients and healthy control groups. The prevalence was 94.4% (17/18) in patients for outpatient control, 94.7% (18/19) in patients who received only medical treatment, 100% (20/20) in patients with exacerbation needed noninvasive ventilation and 84.6% (33/39) in healthy controls. This difference was not statistically significant. However, CP values was statistically different in all the patient groups from the control group. TTV DNA prevalence was higher in patients than healthy individuals. More interesting thing, viral load was highest in the patients with exacerbation needed noninvasive ventilation. As a result, TTV may be associated with COPD and the severity of it.en_US
dc.description.sponsorshipScientific Research Projects (BAP) Coordination of University [2013/131218012]en_US
dc.description.sponsorshipThe authors are grateful to acknowledge the Scientific Research Projects (BAP) Coordination of University for grant with grant number (No. 2013/131218012).en_US
dc.identifier.endpage3466en_US
dc.identifier.issn1940-5901
dc.identifier.issue10en_US
dc.identifier.pmid25419383en_US
dc.identifier.scopus2-s2.0-84910076735en_US
dc.identifier.startpage3461en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17661
dc.identifier.volume7en_US
dc.identifier.wosWOS:000345121100041en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal Of Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTorque Teno Virusen_US
dc.subjectChronic Obstructive Pulmonary Diseaseen_US
dc.titleThe presence of Torque teno virus in chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US

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