Corneal nerve fibre damage precedes diabetic retinopathy in patients with Type2 diabetes mellitus

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dc.contributor.authorBitirgen, G.
dc.contributor.authorOzkagnici, A.
dc.contributor.authorMalik, R. A.
dc.contributor.authorKerimoglu, H.
dc.date.accessioned2024-02-23T14:24:04Z
dc.date.available2024-02-23T14:24:04Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractAims To quantify the morphological alterations in corneal nerve fibres and cells in patients with Type2 diabetes mellitus in relation to the severity of diabetic retinopathy. Methods One hundred and thirty-two eyes of 132 patients with Type2 diabetes and 32 eyes of 32 healthy control subjects were evaluated with in vivo corneal confocal microscopy. Patients with diabetes were classified into three groups: patients without diabetic retinopathy, patients with non-proliferative diabetic retinopathy and patients with proliferative diabetic retinopathy. Anterior and posterior stromal keratocyte, endothelial cell and basal epithelial cell densities and sub-basal nerve fibre structure were evaluated. Results Significant reductions in basal epithelial cell, anterior stromal keratocyte and endothelial cell densities were observed only in patients with diabetic retinopathy. However, nerve fibre density, nerve branch density and nerve fibre length were reduced in patients without diabetic retinopathy and worsened progressively with increasing severity of retinopathy. Conclusions Corneal cell pathology occurs in patients with diabetic retinopathy, but corneal nerve fibre damage seems to precede the development of diabetic retinopathy.en_US
dc.identifier.doi10.1111/dme.12324
dc.identifier.endpage438en_US
dc.identifier.issn0742-3071
dc.identifier.issn1464-5491
dc.identifier.issue4en_US
dc.identifier.pmid24117485en_US
dc.identifier.scopus2-s2.0-84896127757en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage431en_US
dc.identifier.urihttps://doi.org/10.1111/dme.12324
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13806
dc.identifier.volume31en_US
dc.identifier.wosWOS:000332758400009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDiabetic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleCorneal nerve fibre damage precedes diabetic retinopathy in patients with Type2 diabetes mellitusen_US
dc.typeArticleen_US

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