Chemoprotective effect of vitamin E in cyclophosphamide-induced hepatotoxicity in rats

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dc.contributor.authorCuce, Gokhan
dc.contributor.authorCetinkaya, Seda
dc.contributor.authorKoc, Tugba
dc.contributor.authorEsen, Haci Hasan
dc.contributor.authorLimandal, Cisem
dc.contributor.authorBalci, Tevfik
dc.contributor.authorKalkan, Serpil
dc.date.accessioned2024-02-23T14:02:23Z
dc.date.available2024-02-23T14:02:23Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractCyclophosphamide (CP) has a range of adverse effects on liver tissue in humans and animals. Administering an antioxidant with CP might reduce such side effects. Therefore, we examined the role of vitamin E in CP-induced liver toxicity in rats. Male Wistar albino rats were divided into four groups, each of seven rats: control, CP only, CP + vitamin E, and vitamin E only groups. The rats were administered treatments intraperitoneally for 7 days. Then the serum malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate transaminase (AST), and lactate dehydrogenase (LDH) levels were determined while the livers were removed, tissue was prepared using routine histological procedures, sections were stained using hematoxylin and eosin, and the terminal deoxynucleotidyl transferase-mediated nick end-labeling (TUNEL) method was applied. Histopathologically, CP caused hydropic degeneration, necrosis, pleomorphism, and mitotic activity. The number of TUNEL-positive cells and the MDA and ALT levels were significantly higher in the CP group. The antioxidant effects of vitamin E significantly decreased the number of TUNEL-positive cells and the ALT and MDA levels, and normalized the liver histopathology. CP induces apoptosis, has toxic effects on liver tissue, and changes the histological structure. The administration of vitamin E prevented the liver tissue damage caused by CP. (C) 2015 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.cbi.2015.02.016
dc.identifier.endpage11en_US
dc.identifier.issn0009-2797
dc.identifier.issn1872-7786
dc.identifier.pmid25779342en_US
dc.identifier.scopus2-s2.0-84925280162en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.1016/j.cbi.2015.02.016
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11688
dc.identifier.volume232en_US
dc.identifier.wosWOS:000353741300002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofChemico-Biological Interactionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectVitamin Een_US
dc.subjectRaten_US
dc.subjectCyclophosphamideen_US
dc.subjectLiveren_US
dc.titleChemoprotective effect of vitamin E in cyclophosphamide-induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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