The impact of fatigue on patients with psoriatic arthritis: a multi-center study of the TLAR-network

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dc.contributor.authorDuruoz, Mehmet Tuncay
dc.contributor.authorGezer, Halise Hande
dc.contributor.authorNas, Kemal
dc.contributor.authorKilic, Erkan
dc.contributor.authorSargin, Betul
dc.contributor.authorAcer Kasman, Sevtap
dc.contributor.authorAlkan, Hakan
dc.date.accessioned2024-02-23T13:43:43Z
dc.date.available2024-02-23T13:43:43Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractFatigue is a substantial problem in patients with psoriatic arthritis (PsA) that needs to be considered in the core set of domains. This study aimed to evaluate fatigue and its relationship with disease parameters, functional disability, anxiety, depression, quality of life, and correlation with disease activity as determined by various scales. A total of 1028 patients (677 females, 351 males) with PsA who met the CASPAR criteria were included [Turkish League Against Rheumatism (TLAR) Network multicenter study]. The demographic features and clinical conditions of the patients were recorded. Correlations between fatigue score and clinical parameters were evaluated using the Disease Activity Score 28 (DAS28), Disease Activity in Psoriatic Arthritis (DAPSA), Clinical DAPSA (cDAPSA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Fibromyalgia Rapid Screening Tool (FiRST), minimal disease activity (MDA), and very low disease activity (VLDA). Fatigue was assessed with the Functional Assessment of Chronic Illness Therapy (FACIT-F) and a 10-point VAS (VAS-F). The mean age of the patients was 47 (SD: 12.2) years, and the mean disease duration was 6.4 (SD: 7.3) years. The mean VAS-F score was 5.1 (SD: 2.7), with fatigue being absent or mild, moderate, and severe in 12.8%, 24.6%, and 62.5% of the patients, respectively. Fatigue scores were significantly better in patients with DAS28 remission, DAPSA remission, cDAPSA remission, MDA, and VLDA (p < 0.001). Fatigue scores significantly increased with increasing disease activity levels on the DAS28, DAPSA, and cDAPSA (p < 0.001). VAS-F scores showed correlations with the scores of the BASDAI, BASFI, PsAQoL, HAD-A, FiRST, pain VAS, and PtGA. FiRST scores showed fibromyalgia in 255 (24.8%) patients. FACIT-F and VAS-F scores were significantly higher in patients with fibromyalgia (p < 0.001). In regression analysis, VLDA, BASDAI score, FiRST score, high education level, HAD-Anxiety, and BMI showed independent associations with fatigue. Our findings showed that fatigue was a common symptom in PsA and disease activity was the most substantial predictor, with fatigue being less in patients in remission, MDA, and VLDA. Other correlates of fatigue were female gender, educational level, anxiety, quality of life, function, pain, and fibromyalgia.en_US
dc.identifier.doi10.1007/s00296-020-04628-y
dc.identifier.endpage1815en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue11en_US
dc.identifier.pmid32564159en_US
dc.identifier.scopus2-s2.0-85086788470en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1803en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-020-04628-y
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10886
dc.identifier.volume40en_US
dc.identifier.wosWOS:000541406200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPsoriatic Arthritisen_US
dc.subjectFatigueen_US
dc.subjectLassitudeen_US
dc.subjectDisease Activityen_US
dc.subjectOutcome Measureen_US
dc.titleThe impact of fatigue on patients with psoriatic arthritis: a multi-center study of the TLAR-networken_US
dc.typeArticleen_US

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