Nicotinamide N-methyltransferase expression in squamous cell carcinoma of the vulva

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dc.contributor.authorCelik, Zeliha Esin
dc.contributor.authorAkar, Serra
dc.contributor.authorFindik, Siddika
dc.contributor.authorAytekin, Emine
dc.contributor.authorCelik, Cetin
dc.date.accessioned2024-02-23T14:17:13Z
dc.date.available2024-02-23T14:17:13Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractThe molecular pathways involved in the development of vulvar squamous cell carcinoma (SCC) cancer are not completely known. Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme associated with tumorigenesis and metastasis in a variety of cancers. Its role in vulvar cancer has not been studied, previously. Vulvar SCC, high and low grade squamous intraepithelial lesions (SILs) and benign squamous hyperplasia were analysed immunohistochemically. The mean staining score for vulvar SCC was significantly higher than the score for vulvar squamous hyperplasia (p<.001). The mean relapse-free survival for patients with low and high NNMT expression was 41.4 months (95% CI: 25.6-57.2) and 19.8 months (95% CI: 3.0-36.6), respectively (p=.035). The mean disease-specific survival for patients with low and high NNMT expression was 75.8 months (95% CI: 57.5-94.2) and 27.8 months (95% CI 12.2-43.4), respectively (p=.015). Although quite preliminary, this study showed that NNMT expression was elevated in vulvar SCC compared to benign and premalignant lesions. Additionally, elevated NNMT expression was associated with poor survival. Impact Statement What is already known on this subject? Nicotinamide N-methyltransferase (NNMT) is a methyltransferase, associated with tumour progression, spread and poor prognosis in a variety of cancers. Its upregulation can lead to DNA hypomethylation, which can in turn result in the activation of proto-oncogenes and deactivation of tumour suppressor genes. What do the results of this study add? Although quite preliminary, this study showed that NNMT expression was elevated in vulvar SCC compared to benign and premalignant lesions. Additionally, elevated NNMT expression was associated with poor survival. What are the implications of these findings for clinical practice and/or further research? NNMT has been regarded as a potential target of cancer therapy and its role in vulvar cancer has not been studied, previously. This is the first study to investigate the expression of NNMT in vulvar cancer and associate NNMT elevation with poor survival. NNMT can further be investigated as a possible target of vulvar cancer therapy.en_US
dc.description.sponsorshipSelcuk University Scientific Research Funding [20401089]en_US
dc.description.sponsorshipThis study was financed by Selcuk University Scientific Research Funding (#20401089).en_US
dc.identifier.doi10.1080/01443615.2022.2049722
dc.identifier.endpage2330en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue6en_US
dc.identifier.pmid35499473en_US
dc.identifier.scopus2-s2.0-85132662912en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2325en_US
dc.identifier.urihttps://doi.org/10.1080/01443615.2022.2049722
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13000
dc.identifier.volume42en_US
dc.identifier.wosWOS:000789760400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNicotinamide N-Methyltransferaseen_US
dc.subjectVulvar Canceren_US
dc.subjectSquamous Cell Carcinomaen_US
dc.titleNicotinamide N-methyltransferase expression in squamous cell carcinoma of the vulvaen_US
dc.typeArticleen_US

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