Neonatal and Childhood Outcomes in Offspring of Pregnant Women Using Antidepressant Medications: A Critical Review of Current Meta-Analyses

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dc.contributor.authorUguz, Faruk
dc.date.accessioned2024-02-23T12:58:15Z
dc.date.available2024-02-23T12:58:15Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractThis article reviewed the results of 21 recent meta-analyses examining the relationship between maternal use of antidepressants during pregnancy and negative outcomes in newborns and children. PubMed was searched for meta-analyses published in English between January 1, 2011, and November 30, 2019, by using combinations of the keywordspregnancy, antidepressants, review, meta-analysis, selective serotonin reuptake inhibitors, selective serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, neonatal outcomes, autism spectrum disorders, attention deficit hyperactivity disorder (ADHD), preterm birth, low birth weight, spontaneous abortion, persistent pulmonary hypertension, infant, newborn, children, andoffspring. The present review included a total of 21 relevant meta-analyses that met the inclusion criteria. Most of the meta-analyses reported that compared to non-users, the risks of preterm birth, low birth weight, spontaneous abortion, persistent pulmonary hypertension, autism spectrum disorders, and ADHD in offspring of antidepressant users were significantly higher. Some meta-analyses also noted that the elevated risks were no longer statistically significant when pregnant women with psychiatric diagnoses treated with an antidepressant were compared with control patients who remained untreated. Although this review of current meta-analyses suggests a moderately increased risk of neonatal and childhood outcomes assessed with maternal use of antidepressants, it is difficult to ascertain whether these outcomes are independent of underlying maternal psychiatric disorders.en_US
dc.identifier.doi10.1002/jcph.1724
dc.identifier.endpage158en_US
dc.identifier.issn0091-2700
dc.identifier.issn1552-4604
dc.identifier.issue2en_US
dc.identifier.pmid32840005en_US
dc.identifier.scopus2-s2.0-85089746349en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage146en_US
dc.identifier.urihttps://doi.org/10.1002/jcph.1724
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10614
dc.identifier.volume61en_US
dc.identifier.wosWOS:000561999800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntidepressanten_US
dc.subjectNeonatal Outcomeen_US
dc.subjectPregnancyen_US
dc.subjectPerinatologyen_US
dc.subjectPsychopharmacology (Psp)en_US
dc.titleNeonatal and Childhood Outcomes in Offspring of Pregnant Women Using Antidepressant Medications: A Critical Review of Current Meta-Analysesen_US
dc.typeReview Articleen_US

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