The relationship between colonization of Oxalobacter formigenes serum oxalic acid and endothelial dysfunction in hemodialysis patients: From impaired colon to impaired endothelium

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dc.contributor.authorTurkmen, K.
dc.contributor.authorErdur, F. M.
dc.date.accessioned2024-02-23T14:13:12Z
dc.date.available2024-02-23T14:13:12Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractCardiovascular disease (CVD) remains the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients receiving hemodialysis (HD). Oxalic acid is a uremic retention molecule that has been extensively studied in the pathogenesis of calcium-oxalate stones. Oxalobacter formigenes (O. formigenes), a component of the colonic microbiota, plays an important role in oxalate homeostasis. Little is known regarding the colonization of HD patients by O. formigenes and the exact role of this bacterial species in oxalic acid metabolism in these patients. We hypothesized that oxalic acid may be insufficiently degraded in HD patients due to under colonization of the colon by O. formigenes in these patients. To test this hypothesis, we sought to quantitatively measure fecal O. formigenes levels and serum oxalic acid levels in HD patients. We also suggest that increased oxalic acid levels may be associated with endothelial dysfunction and aortic stiffness, both of which are commonly observed in HD patients. Increased colonization with O. formigenes via the ingestion of prebiotics and probiotics could potentially decrease serum oxalic acid levels and improve cardiovascular outcomes in HD patients. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific Investigation and Project Foundation of Erzincan University Mengucek Gazi Training and Research Hospitalen_US
dc.description.sponsorshipThis study was supported by the Scientific Investigation and Project Foundation of Erzincan University Mengucek Gazi Training and Research Hospital.en_US
dc.identifier.doi10.1016/j.mehy.2015.01.010
dc.identifier.endpage275en_US
dc.identifier.issn0306-9877
dc.identifier.issn1532-2777
dc.identifier.issue3en_US
dc.identifier.pmid25630805en_US
dc.identifier.scopus2-s2.0-84925305866en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage273en_US
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2015.01.010
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12346
dc.identifier.volume84en_US
dc.identifier.wosWOS:000350942200024en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofMedical Hypothesesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleThe relationship between colonization of Oxalobacter formigenes serum oxalic acid and endothelial dysfunction in hemodialysis patients: From impaired colon to impaired endotheliumen_US
dc.typeArticleen_US

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