Abnormal Dynamic Pupillometry Relates to Neurologic Disability and Retinal Axonal Loss in Patients With Multiple Sclerosis

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dc.contributor.authorBitirgen, Gulfidan
dc.contributor.authorAkpinar, Zehra
dc.contributor.authorTurk, Huseyin B.
dc.contributor.authorMalik, Rayaz A.
dc.date.accessioned2024-02-23T14:26:47Z
dc.date.available2024-02-23T14:26:47Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractPurpose: To assess alterations in quantitative dynamic pupil responses to light in relation to neurologic disability and retinal axonal loss in patients with multiple sclerosis (MS). Methods: Twenty-five patients with relapsing-remitting MS and 25 healthy subjects were included in this cross-sectional study. Pupillary responses were measured with an infrared dynamic pupillometry unit, and peripapillary retinal nerve fiber layer (RNFL) thickness was measured with spectral-domain optical coherence tomography. Neurologic disability was assessed by the Expanded Disability Status Scale (EDSS). Patients with a history of optic neuritis (ON) within 6 months were excluded. Only the right eyes were assessed, except in 11 patients with a history of unilateral ON in whom both eyes were further analyzed to evaluate the effect of previous ON. Results: The initial pupil diameter (P = 0.003) and pupil contraction amplitude (P = 0.027) were lower in patients with MS compared with healthy controls. Initial pupil diameter correlated with EDSS score (? = ?0.458; P = 0.021), and RNFL correlated with contraction latency (? = ?0.524; P = 0.007). There were no significant differences in any of the pupil parameters between eyes with and without a history of ON, and between the ON and fellow eyes of the 11 patients with previous unilateral ON. Conclusions: Dynamic pupillometry reveals significant alterations in pupillary light reflex responses associated with neurologic disability and retinal axonal loss, independent of previous ON. Translational Relevance: Dynamic pupillometry is a simple, noninvasive tool that may be useful in detecting autonomic dysfunction in patients with MS.en_US
dc.identifier.doi10.1167/tvst.10.4.30
dc.identifier.issn2164-2591
dc.identifier.issue4en_US
dc.identifier.pmid34004008en_US
dc.identifier.scopus2-s2.0-85115625718en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1167/tvst.10.4.30
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14337
dc.identifier.volume10en_US
dc.identifier.wosWOS:000651608800007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Research Vision Ophthalmology Incen_US
dc.relation.ispartofTranslational Vision Science & Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDynamic Pupillometryen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectOptic Neuritisen_US
dc.subjectPupillary Light Reflexen_US
dc.subjectRetinal Nerve Fiber Layeren_US
dc.titleAbnormal Dynamic Pupillometry Relates to Neurologic Disability and Retinal Axonal Loss in Patients With Multiple Sclerosisen_US
dc.typeArticleen_US

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