Outcomes of reirradiation in the treatment of patients with multiple brain metastases of solid tumors: a retrospective analysis

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dc.contributor.authorAktan, Meryem
dc.contributor.authorKoc, Mehmet
dc.contributor.authorKanyilmaz, Gul
dc.contributor.authorTezcan, Yilmaz
dc.date.accessioned2024-02-23T14:37:37Z
dc.date.available2024-02-23T14:37:37Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractBackground: Patients with multiple brain metastases are often treated with whole brain radiation therapy (WBRT). Second course of WBRT is an important treatment option for patients with clinical or radiological intracranial disease progression. This study examines the outcomes in patients with multiple brain metastases who underwent reirradiation. Methods: We examined the medical records of 34 patients with multiple brain metastases who were treated WBRT. The median dose for the first course of WBRT was 30 Gy (range, 25-30 Gy) and for the second course 25 Gy (range, 20-30 Gy). Statistical analyses were performed with using Cox regression analyses, log-rank test and Kaplan-Meier method. Results: The median Karnofsky performance status (KPS) was 80 (range, 50-100) before reirradiation. Patients with KPS of >70 had a median survival of 11.4 months, compared to 2.2 months with KPS of <= 70 (P=0.012) and patients who have severe symptoms at the time of reirradiation with median survival 2.2 months while those with mild symptoms had a median of 4.8 months survival (P=0.08). The median overall survival for all patients after diagnosis of metastases was 24.7 months, after the re-irradiation WBRT (re-WBRT) it was 5.3 months (95% CI, 4.08-6.62) and from the diagnosis of primary tumor was 27.1 months (95% CI, 17.75-37.04). Conclusions: In select patients who have good performance status and who do not have severe symptoms might benefit from re-WBRT and re-WBRT seems to be associated with minimal toxicity in patients treated with lower palliation doses.en_US
dc.identifier.doi10.3978/j.issn.2305-5839.2015.12.21
dc.identifier.issn2305-5839
dc.identifier.issn2305-5847
dc.identifier.issue21en_US
dc.identifier.pmid26734635en_US
dc.identifier.scopus2-s2.0-85015467053en_US
dc.identifier.urihttps://doi.org/10.3978/j.issn.2305-5839.2015.12.21
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16151
dc.identifier.volume3en_US
dc.identifier.wosWOS:000421426500004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAme Publ Coen_US
dc.relation.ispartofAnnals Of Translational Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrain Metastasisen_US
dc.subjectWhole Brain Radiation Therapy (Wbrt)en_US
dc.subjectReirradiationen_US
dc.subjectSurvivalen_US
dc.titleOutcomes of reirradiation in the treatment of patients with multiple brain metastases of solid tumors: a retrospective analysisen_US
dc.typeArticleen_US

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