Curcumin improves spatial memory and decreases oxidative damage in aged female rats

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dc.contributor.authorBelviranli, Muaz
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorAtalik, Kismet Esra Nurullahoglu
dc.contributor.authorOz, Mehmet
dc.date.accessioned2024-02-23T13:56:01Z
dc.date.available2024-02-23T13:56:01Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractAging induced cognitive impairment has been well documented for many years and several antioxidant strategies have been developed against this impairment. Curcumin is the active component of curcuma longa and has shown antioxidant, antiinflamatory and neuroprotective properties. We hypothesized that curcumin would have an influence on cognitive functions in aged female rats. The purpose of the present study was to investigate the effects of curcumin supplementation on cognitive impairment evaluated by Morris water maze (MWM) as well as the oxidative stress induced by aging in female rats. Rats were randomly divided into either control or curcumin-supplemented groups. Curcumin or vehicle (corn oil) were given once daily for a period of 12 days, beginning 7 days prior to and 5 days during the behavioral tests. Behavioral assessment was performed in MWM. At the end of the behavioral test, blood samples and brain tissues were taken for the analysis of malondialdeyde (MDA), protein carbonyl and glutathione levels. During the training session, curcumin supplementation decreased latency to reach to the platform and the total distance traveled. During the probe trial, curcumin supplementation increased the number of platform crossings. In addition to the behavioral testing, biochemical results showed that MDA levels decreased in brain tissue by curcumin supplementation. It may be concluded that, curcumin supplementation improves cognitive functions by decreasing the lipid peroxidation in brain tissue of aged female rats.en_US
dc.identifier.doi10.1007/s10522-013-9422-y
dc.identifier.endpage196en_US
dc.identifier.issn1389-5729
dc.identifier.issn1573-6768
dc.identifier.issue2en_US
dc.identifier.pmid23609199en_US
dc.identifier.scopus2-s2.0-84878564756en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage187en_US
dc.identifier.urihttps://doi.org/10.1007/s10522-013-9422-y
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11061
dc.identifier.volume14en_US
dc.identifier.wosWOS:000319166600008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBiogerontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCurcuminen_US
dc.subjectAgingen_US
dc.subjectSpatial Learningen_US
dc.subjectMemoryen_US
dc.subjectOxidative Stressen_US
dc.titleCurcumin improves spatial memory and decreases oxidative damage in aged female ratsen_US
dc.typeArticleen_US

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