Comparison of the GenoType® MTBC Molecular Genetic Assay with culture methods in the diagnosis of tuberculosis

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dc.contributor.authorKurtoglu, Muhammet Guzel
dc.contributor.authorOzdemir, Mehmet
dc.contributor.authorKesli, Recep
dc.contributor.authorBaysal, Bulent
dc.date.accessioned2024-02-23T14:40:54Z
dc.date.available2024-02-23T14:40:54Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractIntroduction: Clinical samples from 433 patients pre-diagnosed with tuberculosis in Konya, Turkey, were investigated prospectively to compare the GenoType (R) MTBC test (GenoType (R) MTBC) with conventional gold standard culture methods. Material and methods: Lowenstein Jensen (LJ) and Mycobacteria Growth Indicator Tube (MGIT)-960 culture methods and GenoType (R) MTBC were performed together. Results: Mycobacterium tuberculosis (M. tuberculosis) detection rates were 16.2% by culture methods, 15.4% by GenoType (R) MTBC, and 6% by acid-fast bacilli microscopy. The LJ or MGIT-960 with GenoType (R) MTBC detected M. tuberculosis in 12 samples each that were negative according to the other culture method alone. Among 70 M. tuberculosis-positive samples, detection rates were 37% (26/70) by microscopy and 82.8% (58/70) by LJ and MGIT-960, but 95.7% (67/70) by GenoType (R) MTBC. Conclusions: GenoType (R) MTBC may be used as a beneficial adjunct test to culture methods for the detection of M. tuberculosis.en_US
dc.identifier.doi10.5114/aoms.2012.29216
dc.identifier.endpage318en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue2en_US
dc.identifier.pmid24904667en_US
dc.identifier.scopus2-s2.0-84901062606en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage315en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2012.29216
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16637
dc.identifier.volume10en_US
dc.identifier.wosWOS:000336108100017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMycobacterium Tuberculosisen_US
dc.subjectGenotypeen_US
dc.subjectCultureen_US
dc.titleComparison of the GenoType® MTBC Molecular Genetic Assay with culture methods in the diagnosis of tuberculosisen_US
dc.typeArticleen_US

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