Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents

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dc.contributor.authorCan, Ummugulsum
dc.contributor.authorBuyukinan, Muammer
dc.contributor.authorGuzelant, Asuman
dc.contributor.authorUgur, Ayse
dc.contributor.authorKaraibrahimoglu, Adnan
dc.contributor.authorYabanciun, Sukriye
dc.date.accessioned2024-02-23T14:29:51Z
dc.date.available2024-02-23T14:29:51Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractBackground: Metabolic syndrome (MetS) is a chronic and multifactorial syndrome characterized by a low-grade chronic inflammation, and a major risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In our study, we aimed to investigate the serum levels of high sensitive C-reactive protein (hs-CRP), haptoglobin (Hp), alpha(2)-macroglobulin (alpha(2)-MG), platelet factor-4 (PF-4), fetuin-A, serum amyloid P (SAP) and alpha(1)-acid glycoprotein (AGP) in an adolescent population with MetS. Methods: This study was performed in 43 (18 males, 25 females) MetS adolescents between the ages of 13 and 17 years (14.70 +/- 1.15) and 43 lean controls were matched for age and sex. The serum levels of Hp, alpha(2)-MG, PF-4, fetuin-A, SAP and AGP were measured by using a multi-ELISA technique. Results: Serum Hp, fetuin-A (p < 0.01) and PF-4, hs-CRP, SAP, AGP (p < 0.001) values of the MetS subjects were significantly higher than those of the controls. No difference was found in serum alpha(2)-MG levels between the MetS and control groups (p = 0.184). Conclusions: This finding suggests the possibility of using these markers in diagnosis of MetS in adolescents to prevent future complications.en_US
dc.description.sponsorshipKonya Education and Research Hospitalen_US
dc.description.sponsorshipThis study was financially supported by Konya Education and Research Hospital.en_US
dc.identifier.doi10.1515/jpem-2016-0136
dc.identifier.endpage1283en_US
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue11en_US
dc.identifier.pmid27754964en_US
dc.identifier.scopus2-s2.0-84994904903en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1277en_US
dc.identifier.urihttps://doi.org/10.1515/jpem-2016-0136
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14885
dc.identifier.volume29en_US
dc.identifier.wosWOS:000387506800007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal Of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFetuin-Aen_US
dc.subjectHaptoglobinen_US
dc.subjectAlpha(2)-Macroglobulinen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectPlatelet Factor-4en_US
dc.subjectSerum Amyloid Pen_US
dc.titleInvestigation of the inflammatory biomarkers of metabolic syndrome in adolescentsen_US
dc.typeArticleen_US

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