Evaluation of sialic acid, malondialdehyde and glutathione levels in infertile male

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dc.contributor.authorMenevse, Esma
dc.contributor.authorDursunoglu, Duygu
dc.contributor.authorCetin, Nihal
dc.contributor.authorKorucu, Emine Nedime
dc.contributor.authorErbayram, Fatma Zehra
dc.date.accessioned2024-02-23T14:13:43Z
dc.date.available2024-02-23T14:13:43Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractIntroduction and objectives: Around 15% of productive couples in the world are infertile. Recent years, biochemical mechanisms leads to male infertility are started to research. Redox regulation and oxidative stress (OS) show importance in the pathogenesis of infertility in male. Malondialdehyde (MDA) and Glutathione (GSH) are biochemical indicatives of sperm damage by reactive oxygen species (ROS). In addition, sperm are coated with a thick glycocalyx rich in sialic acids. It is aimed to determine and evaluate the differences between normozoosper-mic and oligozoospermic individuals according to sialic acid, MDA and GSH concentrations and correlations between spermyogram and these parameters. Material and methods: This study was carried out on seminal plasma of individuals who admit-ted to Selcuk University Faculty of Medicine IVF Unit Andrology Laboratory. The groups were divided into two as normozoospermics (n = 30, sperm concentration >= 15 million/mL), and oligozoospermics (n = 30, sperm concentration < 15 million/mL). Spermyogram were evaluated regarding WHO (2010) Kruger criteria. GSH, MDA and sialic acid concentrations were analyzed in seminal plasma. Diagnostic performance of sialic acid has been determined with ROC curve analysis. Results: Sialic acid levels were significantly lower in Normozoospermic than Oligozoosper-mic individuals (p < 0.0001), MDA and GSH levels were not differ significantly in both groups (p > 0.05). Sialic acid correlated significantly with most of the spermyogram findings. When diagnostic performance of sialic acid was evaluated, the cut off value of sialic acid found as 4.175 nmol/mL by ROC curve. Conclusion: High seminal plasma sialic acid levels may be used as a biomarker and sialic acid is important determinant in oligozoospermia. (c) 2022 Asociacion Espan tilde ola de Andrologi acute accent a, Medicina Sexual y Reproductiva. Published by Else-vier Espan tilde a, S.L.U. All rights reserved.en_US
dc.identifier.doi10.1016/j.rol.2021.05.002
dc.identifier.endpage273en_US
dc.identifier.issn1698-031X
dc.identifier.issue4en_US
dc.identifier.pmid35906128en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage266en_US
dc.identifier.urihttps://doi.org/10.1016/j.rol.2021.05.002
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12542
dc.identifier.volume20en_US
dc.identifier.wosWOS:000916957800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Espana Sluen_US
dc.relation.ispartofRevista Internacional De Andrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant Activityen_US
dc.subjectGshen_US
dc.subjectMale Infertilityen_US
dc.subjectMdaen_US
dc.subjectSialic Aciden_US
dc.titleEvaluation of sialic acid, malondialdehyde and glutathione levels in infertile maleen_US
dc.typeArticleen_US

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