Fabrication of antimicrobial poly(3-hydroxybuthyrate)/poly (?-caprolactone) nanofibrous mats loaded with curcumin/?-cylodextrin inclusion complex as potential wound dressing

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dc.contributor.authorErci, Fatih
dc.contributor.authorSariipek, Fatma Bayram
dc.date.accessioned2024-02-23T14:12:45Z
dc.date.available2024-02-23T14:12:45Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractIn recent years, bioactive natural agent-based wound dressings have gained a lot of interest thanks to their biocompatibility, non-toxicity, and antibacterial properties. In this study, poly(3-hydroxybutyrate)/poly(epsilon-cap-rolactone) (PHB/PCL) nanofibrous mats loaded with curcumin-beta cyclodextrin (CUR-CD) inclusion complex, a bioactive agent, were successfully developed using the electrospinning technique. First, the CUR-CD inclusion complex was fabricated and characterized by FT-IR, XRD and UV-Vis analyses. This complex was then incor-porated into the PHB/PCL nanofibers. The structural, morphological, mechanical, wettability, solubility features and antibacterial activity of the CUR-CD-based PHB/PCL nanofibrous mats were investigated. In addition, the release studies of curcumin (CUR) from the PHB/PCL matrix were performed for each nanofiber composite. FE-SEM results displayed that the fiber diameter was the lowest for PHB/PCL/3%CUR-CD at 392.37 nm compared to the others. According to the results, we observed that adding CUR and CUR-CD improved the thermal stability of PHB/PCL nanofibers. The development of the complex between CUR and beta CD was supported by FT-IR analysis. Release test results revealed that the CUR-CD complex contributed to controlled release of CUR from fibers. The plate counting technique was used to examine the antibacterial activity nanofibrous mats. The antibacterial activity of PHB/PCL was significantly enhanced by incorporating the CUR-CD complex, particularly against Gram-positive Staphylococcus aureus. After 6 h of contact, the PHB/PCL/10%CUR-CD nanofiber mat exhibited a remarkable 97.79 % reduction in bacterial growth. The results demonstrated that the fabricated PHB/PCL/CUR-CD nanofibrous mats could be potential candidates for use as a wound dressing.en_US
dc.identifier.doi10.1016/j.jddst.2023.105023
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85173478822en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2023.105023
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12161
dc.identifier.volume89en_US
dc.identifier.wosWOS:001100007100001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal Of Drug Delivery Science And Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhben_US
dc.subjectPclen_US
dc.subjectCurcumin-Cyclodextrin Inclusion Complexen_US
dc.subjectElectrospinningen_US
dc.subjectAntimicrobial Nanofiberen_US
dc.subjectWound Dressingen_US
dc.titleFabrication of antimicrobial poly(3-hydroxybuthyrate)/poly (?-caprolactone) nanofibrous mats loaded with curcumin/?-cylodextrin inclusion complex as potential wound dressingen_US
dc.typeArticleen_US

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