Effect of Asbestos Exposure on the Frequency of EGFR Mutations and ALK/ROS1 Rearrangements in Patients With Lung Adenocarcinoma A Multicentric Study

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dc.contributor.authorYilmaz, Senay
dc.contributor.authorDemirci, Nilgun Yilmaz
dc.contributor.authorMetintas, Selma
dc.contributor.authorZamani, Adil
dc.contributor.authorKaradag, Mehmet
dc.contributor.authorGuclu, Ozge A.
dc.contributor.authorKabalak, Pinar Akin
dc.date.accessioned2024-02-23T14:21:12Z
dc.date.available2024-02-23T14:21:12Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis.en_US
dc.identifier.doi10.1097/JOM.0000000000002115
dc.identifier.endpage243en_US
dc.identifier.issn1076-2752
dc.identifier.issn1536-5948
dc.identifier.issue3en_US
dc.identifier.pmid33399308en_US
dc.identifier.scopus2-s2.0-85102602399en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage238en_US
dc.identifier.urihttps://doi.org/10.1097/JOM.0000000000002115
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13491
dc.identifier.volume63en_US
dc.identifier.wosWOS:000663719200021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Occupational And Environmental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlken_US
dc.subjectAsbestosen_US
dc.subjectEgfren_US
dc.subjectGenetic Alterationsen_US
dc.subjectLung Adenocarcinomaen_US
dc.subjectRos1en_US
dc.titleEffect of Asbestos Exposure on the Frequency of EGFR Mutations and ALK/ROS1 Rearrangements in Patients With Lung Adenocarcinoma A Multicentric Studyen_US
dc.typeArticleen_US

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