New Biomarkers Used in the Diagnosis of Tuberculosis-Related Pleural Effusions

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dc.contributor.authorTeke, Turgut
dc.date.accessioned2024-02-23T14:16:58Z
dc.date.available2024-02-23T14:16:58Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractTuberculosis-related pleural effusion (TPE) is reported in 12 to 38% of thoracic tuberculosis (TB) cases in the pediatric population. In TPE, the pleural fluid bacilli load is very low, generally resulting in negative acid-fast bacill (AFB) staining and Mycobacterium culture. In the pleural fluid, AFB stain positivity is reported in <20%, and Mycobacterium tuberculosis positive culture in 18 to 38%. In childhood, this ratio is even lower. Also, pleural effusion (PE) mycobacterial culture gives late results (2-8 weeks). Therefore, TPE is diagnosed with pleura biopsy and pleural liquid examination. However, pleura biopsy is a more invasive operation and the diagnosis rates vary. The clinical and laboratory findings are not typical; it is very hard to distinguish between TPE and another cause of exudative PE. This situation makes it essential for research on reliable new biomarkers that can provide fast and accurate diagnosis of TPE. Adenosine deaminase (ADA) activity being above 40 to 50 U/L (despite varying depending on age) strongly suggests TPE. Other new biomarkers featured in TPE diagnosis are interferon-gamma, cytokines, and nucleic acid multiplication tests. However, the results of ADA and other potential biomarkers shown to be beneficial in TPE diagnosis should always be interpreted with clinical and microbiological findings because no biomarker can provide information about M. tuberculosis culture and drug resistance. Especially in countries with high resistance against TB drugs, performing pleura biopsy, culture and drug resistance tests are important with regard to diagnosis and therapy planning.en_US
dc.identifier.doi10.1055/s-0040-1702216
dc.identifier.endpage117en_US
dc.identifier.issn1305-7707
dc.identifier.issn1305-7693
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85083693343en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.1055/s-0040-1702216
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12861
dc.identifier.volume15en_US
dc.identifier.wosWOS:000528673900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofJournal Of Pediatric Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTuberculosis-Related Pleural Effusionen_US
dc.subjectNew Biomarkersen_US
dc.subjectAdenosine Deaminaseen_US
dc.titleNew Biomarkers Used in the Diagnosis of Tuberculosis-Related Pleural Effusionsen_US
dc.typeArticleen_US

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