Factors affecting pathological response and survival following neoadjuvant chemoradiotherapy in rectal cancer patients

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dc.contributor.authorAktan, Meryem
dc.contributor.authorYavuz, Berrin Benli
dc.contributor.authorKanyilmaz, Gul
dc.contributor.authorOltulu, Pembe
dc.date.accessioned2024-02-23T14:37:47Z
dc.date.available2024-02-23T14:37:47Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground: Despite all advanced treatment methods for rectal cancer, not all patients can provide an adequate response, and hence, possible prognostic factors must be evaluated. The aim of this study was to evaluate the relationship between systemic inflammatory markers and pathological response, overall survival (OS) and disease-free survival (DFS) in patients treated with neoadjuvant chemoradiotherapy (nCRT). Methods: We evaluated data of 117 patients for the period 2010 to 2017. Serum measurements of albumin, hemoglobin, C-reactive protein, modified Glasgow prognostic score (mGPS), and white cell counts were obtained. Rodel scoring system was used to determine pathologic tumor regression. Results: Overall, 77% of the patients were in the good response group according to the radiological images. A total of 48% of patients were categorized as a good pathologic response. Pathologic response to treatment was associated with a mGPS of 0 (P = 0.001), normal platelet lymphocyte ratio (PLR) (P = 0.003), TNM stage (P = 0.03), pathologic T stage (P = 0.001), radiologic response to nCRT (P = 0.04), tumor differentiation (P = 0.001), lymphovascular invasion (LVI) (P = 0.001) and perineural invasion (P = 0.02). LVI (P = 0.04), albumin level (P = 0.05), C-reactive protein (P = 0.01), neutrophil platelet score (NPS) (P = <0.001) and mGPS (P = 0.01) had a statistically significant effect on OS. Operation type (P = 0.03), tumor differentiation (P = 0.01), depth of invasion (P = 0.03), NPS (P < 0.01), mGPS (P = 0.01), PLR (P = 0.004), neutrophil-lymphocyte ratio (P = 0.01) and LVI (P = 0.05) were statistically significant on DFS. Conclusions: There was an association between systemic inflammatory markers and pathologic response and also, between OS and DFS. This study can be preliminary data for prospective controlled studies.en_US
dc.identifier.doi10.4103/ijc.IJC_435_19
dc.identifier.endpage560en_US
dc.identifier.issn0019-509X
dc.identifier.issn1998-4774
dc.identifier.issue4en_US
dc.identifier.pmid33402599en_US
dc.identifier.scopus2-s2.0-85122690604en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage553en_US
dc.identifier.urihttps://doi.org/10.4103/ijc.IJC_435_19
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16239
dc.identifier.volume58en_US
dc.identifier.wosWOS:000756790600011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal Of Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChemoradiotherapyen_US
dc.subjectPathologic Responseen_US
dc.subjectRectal Canceren_US
dc.titleFactors affecting pathological response and survival following neoadjuvant chemoradiotherapy in rectal cancer patientsen_US
dc.typeArticleen_US

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