The level of fatigue, insomnia, depression, anxiety, stress, and the relationship between these symptoms following allogeneic hematopoietic stem cell transplantation: a cross-sectional study

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dc.contributor.authorNoyan, Sumeyye
dc.contributor.authorGundogdu, Fatma
dc.contributor.authorBozdag, Sinem Civriz
dc.date.accessioned2024-02-23T13:55:50Z
dc.date.available2024-02-23T13:55:50Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractPurposeThis study investigated the incidence of fatigue, insomnia, depression, anxiety, and stress symptoms in patients after allogeneic hematopoietic stem cell transplantation (AHSCT), as well as explored potential relationships among these symptoms.MethodsA total of 126 patients who had undergone transplantation at a university hospital at least one month prior to the study's commencement were included. The study was conducted as a cross-sectional and relational research, and data were collected using the Personal Information Form, Brief Fatigue Inventory, Insomnia Severity Index, and Depression Anxiety Stress Scale. Statistical analyses included descriptive statistics, parametric and nonparametric tests, and correlation analyses using the Spearman Correlation Coefficient. Additionally, mediation analyses were conducted using a Structural Equation Model to explore potential causal relationships among the variables.ResultsThe incidence of fatigue was high among patients, with 94% experiencing this symptom following transplantation. Additionally, 52% had anxiety, 47% had insomnia, 47% had depression, and 34% had stress. Moderate relationships were observed between these symptoms. Regression analysis revealed that one-point increase in fatigue was associated with increases in stress 1.065 points, depression 0.937 points, anxiety 0.956 points, and insomnia 0.138 points (p<0.001). Similarly, one-point increase in insomnia was associated with increases in fatigue 3.342 points, stress 0.972 points, depression 0.885 points, and anxiety 0.816 points (p<0.001).ConclusionAfter AHSCT, fatigue was the most frequent symptom experienced by patients, followed by insomnia, depression, anxiety, and stress. There was a relationship between these symptoms. Additionally, evidence suggested that insomnia was more strongly associated with fatigue compared to the other symptoms.en_US
dc.identifier.doi10.1007/s00520-023-07703-9
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.issue4en_US
dc.identifier.pmid36977784en_US
dc.identifier.scopus2-s2.0-85151110294en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s00520-023-07703-9
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10973
dc.identifier.volume31en_US
dc.identifier.wosWOS:001008016300004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofSupportive Care In Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllogeneic Hematopoietic Stem Cell Transplantationen_US
dc.subjectFatigueen_US
dc.subjectInsomniaen_US
dc.subjectDepressionen_US
dc.subjectAnxietyen_US
dc.subjectStressen_US
dc.titleThe level of fatigue, insomnia, depression, anxiety, stress, and the relationship between these symptoms following allogeneic hematopoietic stem cell transplantation: a cross-sectional studyen_US
dc.typeArticleen_US

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