Impaired Thiol-Disulfide Balance in Acute Brucellosis

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dc.contributor.authorKolgelier, Servet
dc.contributor.authorErgin, Merve
dc.contributor.authorDemir, Lutfi Saltuk
dc.contributor.authorInkaya, Ahmet Cagkan
dc.contributor.authorDemir, Nazlim Aktug
dc.contributor.authorAlisik, Murat
dc.contributor.authorErel, Ozcan
dc.date.accessioned2024-02-23T14:44:57Z
dc.date.available2024-02-23T14:44:57Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractThe objective of this study was to examine a novel profile: thiol-disulfide homeostasis in acute brucellosis. The study included 90 patients with acute brucellosis, and 27 healthy controls. Thiol-disulfide profile tests were analyzed by a recently developed method, and ceruloplasmin levels were determined. Native thiol levels were 256.72 +/- 48.20 mu mol/L in the acute brucellosis group and 461.13 +/- 45.37 mu mol/L in the healthy group, and total thiol levels were 298.58 +/- 51.78 mu mol/L in the acute brucellosis group and 504.83 +/- 51.05 mu mol/L in the healthy group (p < 0.001, for both). The disulfide/native thiol ratios and disulfide/total thiol ratios were significantly higher, and native thiol/total thiol ratios were significantly lower in patients with acute brucellosis than in the healthy controls (p < 0.001, for all ratios). There were either positive or negative relationships between ceruloplasmin levels and thiol-disulfide parameters. The thiol-disulfide homeostasis was impaired in acute brucellosis. The strong associations between thiol-disulfide parameters and a positive acute-phase reactant reflected the disruption of the balance between the antioxidant and oxidant systems. Since thiol groups act as anti-inflammatory mediators, the alteration in the thiol-disulfide homeostasis may be involved in brucellosis.en_US
dc.identifier.doi10.7883/yoken.JJID.2016.196
dc.identifier.endpage262en_US
dc.identifier.issn1344-6304
dc.identifier.issn1884-2836
dc.identifier.issue3en_US
dc.identifier.pmid27795469en_US
dc.identifier.scopus2-s2.0-85019958985en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage258en_US
dc.identifier.urihttps://doi.org/10.7883/yoken.JJID.2016.196
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17161
dc.identifier.volume70en_US
dc.identifier.wosWOS:000402693200006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNatl Inst Infectious Diseasesen_US
dc.relation.ispartofJapanese Journal Of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleImpaired Thiol-Disulfide Balance in Acute Brucellosisen_US
dc.typeArticleen_US

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