Cardiovascular effects of resveratrol and atorvastatin treatments in an H2O2-induced stress model

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dc.contributor.authorSoner, Burak Cem
dc.contributor.authorSahin, Ayse Saide
dc.date.accessioned2024-02-23T14:35:26Z
dc.date.available2024-02-23T14:35:26Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractOxidative stress has been implicated in the pathophysiology of several types of cardiovascular disease (CVD). Statins are widely used to inhibit the progression of atherosclerosis and reduce the incidence of CVD. Certain over-the-counter products, including resveratrol, show similar effects to statins and may thus be used in conjunction with statins for the treatment of the majority of patients with CVD. The aim of the present study was to evaluate the effects of atorvastatin, resveratrol and resveratrol + atorvastatin (R+A) pretreatment on myocardial contractions and vascular endothelial functions in the presence of 11209 as an experimental model of oxidative stress in rats. Four groups were established and referred to as the control, atorvastatin, resveratrol and R+A groups. Atorvastatin (40 mg/kg, per oral) and/or resveratrol (30 mg/kg, intraperitoneal) treatments were administered for 14 days. On the 15th day, the thoracic aortas and hearts of the rats were dissected and placed into isolated organ baths. Vascular responses to cumulative doses of H2O2 (1x10(-8)-1x10(-4) M H2O2) with and without N (G)-nitro-L-arginine methyl ester (L-NAME) incubation were measured. In addition, myocardial electrical stimulation (ES) responses to various H2O2 concentrations (1x10(-7)-1x10(-5) M H2O2) were evaluated. In the control and atorvastatin groups, H2O2 application caused a significant dose-dependent decrease in the ES-induced contractions in the myocardial tissue of rats. In the resveratrol and R+A groups, H2O2 application did not significantly affect myocardial contraction at any dose. In all groups, incubatibn with L-NAME caused a significant augmentation in the H2O2 response, revealing that this effect was mediated via the vascular endothelium. In conclusion, pretreatment with R+A for CVD appears to be superior to pretreatment with either agent alone.en_US
dc.identifier.doi10.3892/etm.2014.1956
dc.identifier.endpage1664en_US
dc.identifier.issn1792-0981
dc.identifier.issn1792-1015
dc.identifier.issue5en_US
dc.identifier.pmid25289077en_US
dc.identifier.scopus2-s2.0-84907833758en_US
dc.identifier.startpage1660en_US
dc.identifier.urihttps://doi.org/10.3892/etm.2014.1956
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16028
dc.identifier.volume8en_US
dc.identifier.wosWOS:000344424400056en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpandidos Publ Ltden_US
dc.relation.ispartofExperimental And Therapeutic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectResveratrolen_US
dc.subjectAtorvastatinen_US
dc.subjectMyocardiumen_US
dc.subjectHydrogen Peroxideen_US
dc.subjectEndotheliumen_US
dc.titleCardiovascular effects of resveratrol and atorvastatin treatments in an H2O2-induced stress modelen_US
dc.typeArticleen_US

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