Which part of the blood in the knee joint is responsible for its detrimental effects? (An experimental study on the knee joint in rabbits)

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dc.contributor.authorColak, Tahsin Sami
dc.contributor.authorBicer, Elcil Kaya
dc.contributor.authorKucuk, Levent
dc.contributor.authorDoganavsargil, Basak
dc.contributor.authorSezak, Murat
dc.contributor.authorAydogdu, Semih
dc.date.accessioned2024-02-23T14:24:14Z
dc.date.available2024-02-23T14:24:14Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractAim This study aims to determine the potential causative elements which are responsible for the cartilage damage in case of frequent intra-articular bleeding and to evaluate the effects of intra-articular free iron and chelation of iron in the knee joint. Methods Thirty-five New Zealand rabbits were randomly divided into five groups according to substances injected into their knee joints. Plasma (group I) and cellular components (group II) of the blood harvested from the rabbits, iron (ferric hydroxide sucrose) (group III), iron&chelator (group IV) and only chelator (deferoxamine mesylate) (group V) were injected into their right knees three times a week for 12 weeks. The joint surface was examined histologically according to the classification system modified from Colombo et al. The changes in the synovial tissue were evaluated according to the scoring system modified from Madhok et al. Results Cartilage and synovial abnormality scores were significantly higher in all study groups when compared to their own controls (p < 0.0001). Cartilage scores of groups I and V were significantly lower when compared to groups III and IV (p = 0.002 for group I and p = 0.003 for group V). Synovial abnormality score of group I was significantly lower than scores of groups III and IV (p = 0.001); and of group V lower than groups III and IV (p = 0.003 and p = 0.001, respectively). Conclusions All substances tested in this study caused a certain amount of damage in the cartilage tissue and led to synovial abnormalities. Both iron and iron&chelator caused more damage in the cartilage and led to more advanced synovial changes when compared to the plasma component of blood and chelator itself. Influence of iron and iron&chelators were found to be similar showing that chelation was inadequate in antagonizing the detrimental effects of iron.en_US
dc.identifier.doi10.1111/hae.14605
dc.identifier.endpage871en_US
dc.identifier.issn1351-8216
dc.identifier.issn1365-2516
dc.identifier.issue5en_US
dc.identifier.pmid35732067en_US
dc.identifier.scopus2-s2.0-85132355226en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage865en_US
dc.identifier.urihttps://doi.org/10.1111/hae.14605
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13851
dc.identifier.volume28en_US
dc.identifier.wosWOS:000814337800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofHaemophiliaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntraarticular Bleedingen_US
dc.subjectIntraarticular Ironen_US
dc.subjectIron Chelation Therapyen_US
dc.titleWhich part of the blood in the knee joint is responsible for its detrimental effects? (An experimental study on the knee joint in rabbits)en_US
dc.typeArticleen_US

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