Cholesterol removal from human plasma with biologically modified cryogels

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dc.contributor.authorUzunoglu, Gizem
dc.contributor.authorCimen, Duygu
dc.contributor.authorBereli, Nilay
dc.contributor.authorCetin, Kemal
dc.contributor.authorDenizli, Adil
dc.date.accessioned2024-02-23T14:20:17Z
dc.date.available2024-02-23T14:20:17Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractIn this study, low molecular weight heparin immobilized P(HEMA) cryogels were fabricated for the removal of LDL-C in hypercholesterolemic human plasma. After characterization studies for P(HEMA) cryogels, effects of the parameters including medium pH, CNBr concentration, heparin concentration and contact time on heparin immobilization were investigated. Blood compatibility and cell adhesion tests were also performed, and platelet and leucocyte loss for P(HEMA)-Hp cryogels were found to be 2.95% and 4.91%, respectively. Maximum adsorption capacity for LDL-C from hypercholesterolemic human plasma was found to be 26.7 mg/g for P(HEMA)-Hp cryogel while it was only 1.67 mg/g for bare P(HEMA) cryogel. The P(HEMA)-Hp cryogels exhibit high desorption ratios up to 96% after 10 adsorption-desorption cycles with no significant decrease in the adsorption capacity. The findings indicated that these reusable P(HEMA)-based cryogels proposed good alternative adsorbents for removal of LDL-C.en_US
dc.identifier.doi10.1080/09205063.2019.1627652
dc.identifier.endpage1290en_US
dc.identifier.issn0920-5063
dc.identifier.issn1568-5624
dc.identifier.issue14en_US
dc.identifier.pmid31156065en_US
dc.identifier.scopus2-s2.0-85067685829en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1276en_US
dc.identifier.urihttps://doi.org/10.1080/09205063.2019.1627652
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13105
dc.identifier.volume30en_US
dc.identifier.wosWOS:000475130700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Biomaterials Science-Polymer Editionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAffinity Chromatographyen_US
dc.subjectCryogelen_US
dc.subjectHemoperfusionen_US
dc.subjectHeparinen_US
dc.subjectLdl-C Removalen_US
dc.titleCholesterol removal from human plasma with biologically modified cryogelsen_US
dc.typeArticleen_US

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