Highly selective electrochemical sensor for new generation targeted-anticancer drug Ibrutinib using newly synthesized nanomaterial GO-NH-B(OH)2@AgNPs modified glassy carbon electrode

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dc.contributor.authorAmudi, Karina
dc.contributor.authorYigit, Aybek
dc.contributor.authorMenges, Nurettin
dc.contributor.authorPinar, Pinar Talay
dc.date.accessioned2024-02-23T14:13:11Z
dc.date.available2024-02-23T14:13:11Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractIbrutinib (IBR) is a small molecule new generation smart anti-cancer drug that is Bruton's tyrosine kinase (BTK) inhibitor. In this study, the sensitive and selective electrochemical sensor based on a modification of a glassy carbon electrode with a new GO-NH-B(OH)2 (graphene oxide boramidic acid) nanoparticles and Ag nano -particles (AgNPs) is proposed for IBR determination. GO-NH-B(OH)2@AgNPs/GCE was characterized by scan-ning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV). The performance of the electrode was evaluated with the parameters of electrode surface area (A), heterogeneous rate constant (ket), standard exchange current density (I0). The electrochemical determination of IBR in 0.1 M HNO3 solution was investigated at the surface of GO-NH-B(OH)2@AgNPs/GCE. Under optimized square wave voltammetric (SWV) conditions, peaks current at GO-NH-B(OH)2@AgNPs/GCE showed good linearity with the concentration of IBR in the operating range of 0.025-1.00 mu g mL-1 (5.7 x 10-8 - 2.3 x 10-6 M) with a detection limit (LOD) of 0.006 mu g mL-1 (1.36 x 10-8 M). Besides its high stability and reproducibility, the response of IBR at GO-NH-B (OH)2@AgNPs/GCE was not influenced by the presence of dopamine, uric acid, and ascorbic acid. The sensor has successfully caught IBR in pharmaceutical and human urine samples.en_US
dc.identifier.doi10.1016/j.measurement.2023.112978
dc.identifier.issn0263-2241
dc.identifier.issn1873-412X
dc.identifier.scopus2-s2.0-85159765634en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.measurement.2023.112978
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12340
dc.identifier.volume216en_US
dc.identifier.wosWOS:001001714700001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofMeasurementen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIbrutiniben_US
dc.subjectGraphene Oxide-Boramidic Aciden_US
dc.subjectAg Nanoparticlesen_US
dc.subjectElectrochemical Oxidationen_US
dc.titleHighly selective electrochemical sensor for new generation targeted-anticancer drug Ibrutinib using newly synthesized nanomaterial GO-NH-B(OH)2@AgNPs modified glassy carbon electrodeen_US
dc.typeArticleen_US

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