Oxidant and Antioxidant Status in Children With Subacute Sclerosing Panencephalitis

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dc.contributor.authorCaksen, Huseyin
dc.contributor.authorOzkan, Mustafa
dc.contributor.authorCemek, Mustafa
dc.contributor.authorCemek, Fatma
dc.date.accessioned2024-02-23T14:26:57Z
dc.date.available2024-02-23T14:26:57Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractWe analyzed serum alpha-tocopherol, beta-carotene, retinol, and ascorbic acid levels and malondialdehyde and reduced glutathione concentrations on erythrocyte and cerebrospinal fluid in 30 patients with subacute sclerosing panencephalitis to evaluate oxidant and antioxidant status. Serum alpha-tocopherol, beta-carotene, retinol, ascorbic acid levels, and erythrocyte and cerebrospinal fluid reduced glutathione concentrations were decreased; however, erythrocyte and cerebrospinal fluid malondialdehyde levels were increased in the patients. Cerebrospinal fluid malondialdehyde levels were different between clinical stages of the disease (P < .05). Higher cerebrospinal fluid malondialdehyde level was associated with the more severe clinical stage. A positive correlation was found between cerebrospinal fluid malondialdehyde level and clinical stages (r = 0.42; P < .05) and between erythrocyte malondialdehyde level and clinical stages (r = 0.40; P < .05). Our findings showed presence of oxidative damage in subacute sclerosing panencephalitis and that antioxidants were increased as defense mechanisms of the organism against oxidative damage.en_US
dc.description.sponsorshipYuzuncu Yil University Department of Scientific Research Projects [2010-TF-U75]en_US
dc.description.sponsorshipThe authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The authors received financial support for the research from Yuzuncu Yil University Department of Scientific Research Projects (Project number: 2010-TF-U75).en_US
dc.identifier.doi10.1177/0883073813494475
dc.identifier.endpage1452en_US
dc.identifier.issn0883-0738
dc.identifier.issn1708-8283
dc.identifier.issue11en_US
dc.identifier.pmid23872915en_US
dc.identifier.scopus2-s2.0-84908686151en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1448en_US
dc.identifier.urihttps://doi.org/10.1177/0883073813494475
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14395
dc.identifier.volume29en_US
dc.identifier.wosWOS:000344655400014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofJournal Of Child Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidanten_US
dc.subjectAntioxidanten_US
dc.subjectSubacute Sclerosing Panencephalitisen_US
dc.titleOxidant and Antioxidant Status in Children With Subacute Sclerosing Panencephalitisen_US
dc.typeArticleen_US

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