The LDL/HDL ratio and atherosclerosis in ankylosing spondylitis

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dc.contributor.authorKucuk, A.
dc.contributor.authorUslu, A. Ugur
dc.contributor.authorIcli, A.
dc.contributor.authorCure, E.
dc.contributor.authorArslan, S.
dc.contributor.authorTurkmen, K.
dc.contributor.authorToker, A.
dc.date.accessioned2024-02-23T13:43:46Z
dc.date.available2024-02-23T13:43:46Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractIn ankylosing spondylitis (AS) patients, cardiac and vascular involvement may manifest as atherosclerosis and coronary artery disease. Systemic inflammation, oxidative stress, increased low-density lipoprotein (LDL) cholesterol and decreased high-density lipoprotein (HDL) cholesterol constitute a significant risk for atherosclerosis. This study investigated the relationship between carotid intima-media thickness (CIMT), LDL/HDL ratio, total oxidant status (TOS; an indicator of oxidative stress) and ischemic modified albumin (IMA; an ischemic marker in AS patients). Sixty AS patients were diagnosed using the Modified New York Criteria; 54 age- and gender-matched participants were included as controls. CIMT, LDL/HDL ratio, TOS and IMA were measured using the most appropriate methods. IMA was higher in AS patients compared to controls (p < 0.0001). TOS was also increased in AS patients (p = 0.005); as was CIMT (p < 0.0001). The LDL/HDL ratio was also greater in AS patients compared to controls (p = 0.047). A positive correlation was found between CIMT and LDL/HDL ratio among AS patients. Elevated CIMT, IMA and TOS levels suggest an increased risk of atherosclerotic heart disease in AS patients. The LDL/HDL ratio was higher in AS patients compared to controls, and there was a correlation between LDL/HDL ratio and CIMT, albeit statistically weak. Therefore, the LDL/HDL ratio is not a reliable marker to predict atherosclerotic heart disease in AS patients.en_US
dc.identifier.doi10.1007/s00393-016-0092-4
dc.identifier.endpage63en_US
dc.identifier.issn0340-1855
dc.identifier.issn1435-1250
dc.identifier.issue1en_US
dc.identifier.pmid27312464en_US
dc.identifier.scopus2-s2.0-84975166615en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage58en_US
dc.identifier.urihttps://doi.org/10.1007/s00393-016-0092-4
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10919
dc.identifier.volume76en_US
dc.identifier.wosWOS:000394465400015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofZeitschrift Fur Rheumatologieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDyslipidemiasen_US
dc.subjectAtherosclerosisen_US
dc.subjectAnkylosing Spondylitisen_US
dc.subjectIschemia-Modified Albuminen_US
dc.subjectOxidative Stressen_US
dc.titleThe LDL/HDL ratio and atherosclerosis in ankylosing spondylitisen_US
dc.typeArticleen_US

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