Frequency of Vaginal Candida Colonization and Relationship between Metabolic Parameters in Children with Type 1 Diabetes Mellitus

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dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorAkyurek, Nesibe
dc.contributor.authorEklioglu, Beray Selver
dc.date.accessioned2024-02-23T14:13:01Z
dc.date.available2024-02-23T14:13:01Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractObjectives: Patients with diabetes mellitus (DM) are at risk for vulvovaginal candidasis. The aim of this study was to determine the species-specific prevalence rate and risk of candidiasis in patients with type 1 DM. Methods: Children aged between 8-16 years were included in the study. Clinical and laboratory features of diabetes and evidence of genital symptoms were recorded. Vaginal swabs were taken from patients and placed on Sabouraud's dextrose agar and incubated. Following fasting overnight for 12 hours venous blood samples were taken simultaneously for analyses of blood glucose, HbA1c, and lipid profile. A simple 1-time fiuconazole treatment regimen was used to treat patients with vulvo-vaginal candidiasis. Results: Candida species were isolated in 30 of 76 (39%) swabs of patients with type 1 DM. Subjects who had candida colonization and candidiasis were all acute. The predominant candida species isolated from patients with type 1 DM were C.albicans 50%, C. glabrata 36.6%, C.crusei 3.3%, C.spesies 6.6%, and C.dubliniensis 3.3%. 42 patients had symptoms. The prevalence of candidiasis in symptomatic patients was 59.2%. Subjects with vulvo-vaginal candidiasis had higher mean HbA1c when compared to those who had no such infection (P = .047). Conclusions: There seems to be a significant link between hyperglycemia and vulvo-vaginal candidiasis in patients with type 1 DM. Improving glucose control may reduce the risk of candidiasis and potentially symptomatic infection among children with diabetes. Because of high rate of colonization with candida species in diabetes, patients should undergo periodic screening for genital candidiasis.en_US
dc.identifier.doi10.1016/j.jpag.2013.03.016
dc.identifier.endpage260en_US
dc.identifier.issn1083-3188
dc.identifier.issn1873-4332
dc.identifier.issue5en_US
dc.identifier.pmid24012126en_US
dc.identifier.scopus2-s2.0-84883492519en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage257en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpag.2013.03.016
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12256
dc.identifier.volume26en_US
dc.identifier.wosWOS:000324600800003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal Of Pediatric And Adolescent Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVaginal Colonizationen_US
dc.subjectType 1 Diabetes Mellitusen_US
dc.subjectC.Albicansen_US
dc.titleFrequency of Vaginal Candida Colonization and Relationship between Metabolic Parameters in Children with Type 1 Diabetes Mellitusen_US
dc.typeArticleen_US

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