Prognostic importance of PTEN, EGFR, HER-2, and IGF-1R in gastric cancer patients treated with postoperative chemoradiation

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dc.contributor.authorBenli Yavuz, Berrin
dc.contributor.authorKoc, Mehmet
dc.contributor.authorKozacioglu, Sumeyye
dc.contributor.authorKanyilmaz, Gul
dc.contributor.authorAktan, Meryem
dc.date.accessioned2024-02-23T14:37:22Z
dc.date.available2024-02-23T14:37:22Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractBadcground/aim: This study aimed to describe the prognostic importance of epidermal growth factor (EGFR), phosphatase and tensin homolog (PTEN), human EGF receptor-2 (HER-2), and insulin-like growth factor 1 receptor (IGF-1R) in gastric cancer patients treated with postoperative chemoradiation therapy. Materials and methods: Sixty-nine patients treated with adjuvant chemoradiation therapy were retrospectively evaluated. Tumor samples were stained immunohistochemically. Results: All patients were treated with 3D conformal radiation therapy with concomitant and adjuvant chemotherapy. Perineural invasion (PNI) (P = 0.042), prechemoradiation therapy albumin levels below 3.5 mg/dL (P = 0.011), and EGFR positivity (P = 0.008) had negative effects on overall survival (OS). The median OS was 26 months for patients with PNI (+), 34.9 months for those with PNI (-), 19.5 months for those with albumin levels below 3.5 mg/dL, and 33.2 months for those with albumin levels above 3.5 mg/dL. IGF-1R (+) (P= 0.035) and history of cigarette smoking (P= 0.033) were observed to have a statistically significantly negative effect on disease-free survival (DFS). The median DFS was 29.2 months for IGF-1R (+) patients, 37.9 months for those with IGF-1R (-), and 26.3 and 40.59 months for smokers and nonsmokers, respectively. Condusion: IGF-1R and EGFR may be used for patient selection in future prospective studies that evaluate the prognostic importance of these receptors.en_US
dc.description.sponsorshipScientific and Research Council of Necmettin Erbakan University [141618023]en_US
dc.description.sponsorshipThis study was presented as a digital poster discussion session at the 56th ASTRO Annual Meeting, 14-17 September 2014, San Francisco, CA, USA. This project was supported by the Scientific and Research Council of Necmettin Erbakan University, Project Number 141618023.en_US
dc.identifier.doi10.3906/sag-1802-34
dc.identifier.endpage1032en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.pmid31318186en_US
dc.identifier.scopus2-s2.0-85071352145en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1025en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1802-34
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16078
dc.identifier.volume49en_US
dc.identifier.wosWOS:000480360000009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastric Canceren_US
dc.subjectPtenen_US
dc.subjectEgfren_US
dc.subjectHer-2en_US
dc.subjectIgf-1ren_US
dc.subjectRadiotherapyen_US
dc.titlePrognostic importance of PTEN, EGFR, HER-2, and IGF-1R in gastric cancer patients treated with postoperative chemoradiationen_US
dc.typeArticleen_US

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