CeO2-ZrO2 Nanoparticle-Modified Enzymatic Lactate Biosensors with Reduced Oxygen Susceptibility

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dc.contributor.authorUzunoglu, Aytekin
dc.date.accessioned2024-02-23T14:26:27Z
dc.date.available2024-02-23T14:26:27Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractIn the present work, the development of novel CeO2-ZrO2 nanoparticle-modified sensing platforms was described to address the oxygen dependency of lactate oxidase enzyme-based electrochemical lactate biosensors. Using engineered electrode modification, it was aimed to construct enzymatic lactate sensors capable of working in O-2-depleted environments. In this regard, CeO2-ZrO2 nanoparticles were chosen as electrode modifiers due to their high oxygen release and uptake properties. The nanoparticles were prepared using a facile chemical synthesis method and characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), Raman spectroscopy, and N-2 adsorption methods. The XRD and TEM results confirmed the successful synthesis of CeO2-ZrO2 nanoparticles and a physical surface area of 76.1 m(2) g(-1) was measured by BET method. The electrochemical performance results demonstrated that CeO2-ZrO2 nanoparticle-modified biosensors showed high sensitivities regardless of the subjected environments. In contrast to conventional enzymatic lactate biosensors, novel sensor design experienced only a slight drop in the response in O-2-depleted solutions, confirming that the O-2-susceptibility of the lactate biosensors was diminished significantly. The novel biosensor design showed a high sensitivity of 138.9 +/- 1.2 mu A. mM(-1). cm(-2) with the linear range of 2.5 mu M-0.6 mM. (C) 2018 The Electrochemical Society.en_US
dc.identifier.doi10.1149/2.0601810jes
dc.identifier.endpageB441en_US
dc.identifier.issn0013-4651
dc.identifier.issn1945-7111
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85053752214en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageB436en_US
dc.identifier.urihttps://doi.org/10.1149/2.0601810jes
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14199
dc.identifier.volume165en_US
dc.identifier.wosWOS:000441061800056en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElectrochemical Soc Incen_US
dc.relation.ispartofJournal Of The Electrochemical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleCeO2-ZrO2 Nanoparticle-Modified Enzymatic Lactate Biosensors with Reduced Oxygen Susceptibilityen_US
dc.typeArticleen_US

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