Role of oxidative stress and serum lipid levels in stable chronic obstructive pulmonary disease

Basit Öğe Kaydı
dc.contributor.authorCan, Ummugulsum
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorYosunkaya, Sebnem
dc.date.accessioned2024-02-23T14:12:38Z
dc.date.available2024-02-23T14:12:38Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractBackground: Chronic obstructive pulmonary disease (COPD) has been associated with increased oxidative stress or reduced antioxidant resources. The main goal of this study was to evaluate the levels of serum ischemia-modified albumin (IMA), oxidized low-density lipoprotein (ox-LDL), total oxidant status (TOS), and total antioxidant status in patients with stable COPD, compared with a control group. Methods: This study was performed on 51 patients with stable COPD (42 men and 9 women; mean age 56.92 +/- 3.0 years) and 45 healthy control participants (32 men and 13 women; 54.8 +/- 3.8 years). The levels of serum lipids, IMA, total antioxidant status, TOS, and ox-LDL were measured in all participants. Results: The levels of serum IMA, ox-LDL, and TOS were significantly higher in patients with COPD than those in control individuals. There was no difference between the levels of serum total antioxidant status, triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C) of patients with COPD and those of control individuals. Serum high-density lipoprotein cholesterol levels were significantly lower in patients with COPD than in control individuals. Conclusion: Our study indicated that serum IMA, ox-LDL, and TOS may be increased as a result of chronic hypoxia, inflammation, and oxidative stress in patients with severe and very severe stable COPD. Our findings also revealed that IMA is higher in. patients with Global Initiative for Chronic Obstructive Lung Disease Stages II, III, and IV, while TOS and ox-LDL are higher in patients with Global Initiative for Chronic Obstructive Lung Disease Stage IV. Measurements of serum IMA, TOS, and ox-LDL levels may be useful markers in the evaluation of stable COPD. Copyright (C) 2015 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.en_US
dc.description.sponsorshipKonya Education and Research Hospital, Turkey [49]en_US
dc.description.sponsorshipThis study was financially supported by Konya Education and Research Hospital (grant no. 49), Turkey.en_US
dc.identifier.doi10.1016/j.jcma.2015.08.004
dc.identifier.endpage708en_US
dc.identifier.issn1726-4901
dc.identifier.issn1728-7731
dc.identifier.issue12en_US
dc.identifier.pmid26431591en_US
dc.identifier.scopus2-s2.0-84948822811en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage702en_US
dc.identifier.urihttps://doi.org/10.1016/j.jcma.2015.08.004
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12139
dc.identifier.volume78en_US
dc.identifier.wosWOS:000367125600004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of The Chinese Medical Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic Obstructive Pulmonary Diseaseen_US
dc.subjectIschemia-Modified Albuminen_US
dc.subjectOxidative Stressen_US
dc.subjectOxidized Low-Density Lipoproteinen_US
dc.subjectTotal Oxidant Statusen_US
dc.titleRole of oxidative stress and serum lipid levels in stable chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US

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