Synthesis of asymmetrical tridendate Schiff bases and metal complexes and investigation of anticarcinogen effects on human colon and cervical cancers

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dc.contributor.authorSahin, Mustafa
dc.contributor.authorKorkmaz, Hatice
dc.contributor.authorKocak, Nuriye
dc.contributor.authorSahin, Ozlem
dc.contributor.authorKarakurt, Serdar
dc.contributor.authorYilmaz, Mustafa
dc.date.accessioned2024-02-23T14:20:29Z
dc.date.available2024-02-23T14:20:29Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractThe metal complexes of Zn(II), Ni(II), Cu(II) and Pb(II) with asymmetrical Schiff bases were synthesized. The asymmetrical Schiff base was obtained through the condensation of 1,2-phenylenediamine, 4-methyl-1,2-phenylenediamine, 2-hydroxy-1-napthaldehyde and biphenyl-4-carbaldehyde. The new Schiff base ligands (L-1' and L-2') and their metal complexes were characterized by TG/DTG, FT-IR, H-1-NMR, UV-Vis, ESR, powder XRD, elemental analysis, magnetic moment and fluorescence studies. The powder XRD studies indicate that Co(II) and Cu(II) complexes are amorphous, while Ni(II) and Zn(II) complexes are crystalline. The anticarcinogenic effects of L-1' and L-2' were also investigated against colon (SW-620) and cervical cancer (HeLa) cell lines and compound L-2' was found to possess the highest anticarcinogenic potential, with 16.7 mu M and 27.5 mu M of IC50 values for HeLa and SW620 cells, respectively.en_US
dc.description.sponsorshipSelcuk University Research Foundation [14201023]en_US
dc.description.sponsorshipThis study was supported by Selcuk University Research Foundation with project number: 14201023.en_US
dc.identifier.doi10.1080/10601325.2017.1294451
dc.identifier.endpage300en_US
dc.identifier.issn1060-1325
dc.identifier.issn1520-5738
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85017607971en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage288en_US
dc.identifier.urihttps://doi.org/10.1080/10601325.2017.1294451
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13168
dc.identifier.volume54en_US
dc.identifier.wosWOS:000399809000003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Macromolecular Science Part A-Pure And Applied Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticancer Activityen_US
dc.subjectEsren_US
dc.subjectMetal Complexesen_US
dc.subjectSchiff Baseen_US
dc.subjectXrden_US
dc.titleSynthesis of asymmetrical tridendate Schiff bases and metal complexes and investigation of anticarcinogen effects on human colon and cervical cancersen_US
dc.typeArticleen_US

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