Dynamic thiol-disulfide homeostasis is disturbed in patients with non-alcoholic fatty liver disease

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dc.contributor.authorAsil, Mehmet
dc.contributor.authorDertli, Ramazan
dc.contributor.authorBiyik, Murat
dc.contributor.authorYolacan, Ramazan
dc.contributor.authorErel, Ozcan
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorAtaseven, Huseyin
dc.date.accessioned2024-02-23T14:31:53Z
dc.date.available2024-02-23T14:31:53Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractBackground: Oxidative stress has been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Plasma thiols are major defense mechanisms against oxidative stress and undergo oxidation to form disulfides under oxidative conditions. This study was conducted to investigate thiol-disulfide homeostasis in NAFLD patients. Methods: Thirty patients with biopsy proven non-alcoholic steatohepatitis (NASH), 40 patients with simple steatosis and 50 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measured using the Erel and Neselioglu's method. Results: The mean serum total thiol concentrations in the NASH, simple steatosis and control groups were 415 +/- 64 mu mol/L, 447 +/- 38 mu mol/L and 480 +/- 37 mu mol/L, respectively (p < 0.001). The mean serum native thiol concentrations in the NASH, simple steatosis and control groups were 378 +/- 62 mu mol/L, 416 +/- 41 mu mol/L and 451 +/- 36 mu mol/L, respectively (p < 0.001). The mean serum disulfide concentrations in the NASH, simple steatosis and control groups were 18.5 +/- 6.3 mu mol/L, 15.5 +/- 4.8 mu mol/L and 14.9 +/- 3.6 mu mol/L, respectively (p = 0.005). The native thiol/total thiol ratio was significantly lower and the disulfide/total thiol and disulfide/native thiol ratios were significantly higher in the NASH group than in the simple steatosis and control groups. Conclusions: Thiol-disulfide homeostasis is disturbed and shifted toward disulfide side in NAFLD and NASH patients.en_US
dc.identifier.doi10.1515/labmed-2017-0018
dc.identifier.endpage38en_US
dc.identifier.issn2567-9430
dc.identifier.issn2567-9449
dc.identifier.issue1.Şuben_US
dc.identifier.scopus2-s2.0-85056395451en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://doi.org/10.1515/labmed-2017-0018
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15390
dc.identifier.volume42en_US
dc.identifier.wosWOS:000429039300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal Of Laboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDisulfidesen_US
dc.subjectFatty Liveren_US
dc.subjectOxidative Stressen_US
dc.subjectSteatohepatitisen_US
dc.subjectThiolsen_US
dc.titleDynamic thiol-disulfide homeostasis is disturbed in patients with non-alcoholic fatty liver diseaseen_US
dc.typeArticleen_US

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