Effects of Naringenin on Oxidative Stress and Histopathological Changes in the Liver of Lead Acetate Administered Rats

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dc.contributor.authorOzkaya, Ahmet
dc.contributor.authorSahin, Zafer
dc.contributor.authorDag, Uzeyir
dc.contributor.authorOzkaraca, Mustafa
dc.date.accessioned2024-02-23T12:11:10Z
dc.date.available2024-02-23T12:11:10Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractLead has several adverse effects on the body due to one of the environmental pollutants. We aimed to determine the effects of naringenin on the oxidative stress and the hepatic damage against lead acetate treatment in the liver of male rats. Naringenin was administered by orogastric gavage (50 mg/kg) and lead acetate was given as daily 500 parts per million in drinking water for 4 weeks. Lead and antioxidant activities were measured, and histopathological evaluation was performed in the liver. Lead concentrations, malondialdehyde, and antioxidant activity were restored by the naringenin. The grade of necrosis, hydropic degeneration, and hepatic cord disorganization was decreased by the naringenin. However, there were no differences in the degree of sinusoidal congestion, hepatic steatosis, and capsular fibrosis between lead acetate and naringenin + lead acetate groups. We can suggest that naringenin has antioxidant and chelating effects in the liver. Nevertheless, this effect is not enough against the lead acetate induced hepatic injury. (C) 2016 Wiley Periodicals, Inc.en_US
dc.description.sponsorshipScientific Research Projects Unit of Adiyaman University (ADYUBAP) [FEFYL-2011/0015]en_US
dc.description.sponsorshipContract Grant Sponsor: Scientific Research Projects Unit of Adiyaman University (ADYUBAP).; Contract Grant Number: FEFYL-2011/0015.en_US
dc.identifier.doi10.1002/jbt.21785
dc.identifier.endpage248en_US
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue5en_US
dc.identifier.pmid26929248en_US
dc.identifier.scopus2-s2.0-84959564701en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage243en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.21785
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10573
dc.identifier.volume30en_US
dc.identifier.wosWOS:000378507100005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Biochemical And Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNaringeninen_US
dc.subjectAntioxidanten_US
dc.subjectLiver Injuryen_US
dc.subjectLead Acetateen_US
dc.titleEffects of Naringenin on Oxidative Stress and Histopathological Changes in the Liver of Lead Acetate Administered Ratsen_US
dc.typeArticleen_US

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