Does the serum uric acid level have any relation to arterial stiffness or blood pressure in adults with congenital renal agenesis and/or hypoplasia?

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dc.contributor.authorYazici, Raziye
dc.contributor.authorGuney, Ibrahim
dc.contributor.authorAltintepe, Lutfullah
dc.contributor.authorYazici, Mehmet
dc.date.accessioned2024-02-23T14:20:29Z
dc.date.available2024-02-23T14:20:29Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractBackground: The relationship between serum uric acid and arterial stiffness or blood pressure is not clear. The serum uric acid level and its association with cardiovascular risk is not well known in patients with reduced renal mass. We aimed to investigate the relation between serum uric acid levels and arterial stiffness and also blood pressure in patients with congenital renal agenesis and/or hypoplasia. Material and Methods: In this single center, cross-sectional study, a total of 55 patients (39 (% 70.9) with unilateral small kidney and 16 (% 29.1) with renal agenesis) were included. The median age was 35 (21-50) years. The study population was divided into tertiles of serumuric acid (according to 2.40-3.96, 3.97-5.10, and 5.11-9.80mg/dl cut-off values of serum uric acid levels). Official and 24-h ambulatory non-invasive blood pressures of all patients were measured. The arterial stiffness was assessed by pulse wave velocity (PWV). Results: PWV values were increased from first to third tertile (5.5 +/- 0.6, 5.7 +/- 0.8, 6.1 +/- 0.7, respectively), but this gradual increase between tertiles did not reach significance. Linear regression analyses showed a positive correlation between serum uric acid levels and PWV (beta = 0.40, p = 0.010), but no correlation was found between uric acid and daytime systolic blood pressure (beta = 0.24, p = 0.345). Conclusion: In congenital renal agenesis/hypoplasia, the serumuric acid level was positively correlated with arterial stiffness, but there was no correlation with blood pressure.en_US
dc.description.sponsorshipEducational Planning Commission of the Konya Education and Research Hospitalen_US
dc.description.sponsorshipThis research was supported by Educational Planning Commission of the Konya Education and Research Hospital.en_US
dc.identifier.doi10.1080/10641963.2016.1210630
dc.identifier.endpage149en_US
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006
dc.identifier.issue2en_US
dc.identifier.pmid28287880en_US
dc.identifier.scopus2-s2.0-85014552679en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://doi.org/10.1080/10641963.2016.1210630
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13172
dc.identifier.volume39en_US
dc.identifier.wosWOS:000396749000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofClinical And Experimental Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArterial Stiffnessen_US
dc.subjectHypoplastic Kidneyen_US
dc.subjectPulse Wave Velocityen_US
dc.subjectRenal Agenesiaen_US
dc.subjectUric Aciden_US
dc.titleDoes the serum uric acid level have any relation to arterial stiffness or blood pressure in adults with congenital renal agenesis and/or hypoplasia?en_US
dc.typeArticleen_US

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