Effects of Adipose-Derived Stem Cells and Platelet-Rich Plasma for Prevention of Alopecia and Other Skin Complications of Radiotherapy

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dc.contributor.authorEvin, Nuh
dc.contributor.authorTosun, Zekeriya
dc.contributor.authorAktan, Tahsin Murad
dc.contributor.authorDuman, Selcuk
dc.contributor.authorHarmankaya, Ismail
dc.contributor.authorYavas, Guler
dc.date.accessioned2024-02-23T14:21:23Z
dc.date.available2024-02-23T14:21:23Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description30th Annual Meeting of the European-Association-of-Plastic-Surgeons (EURAPS) -- MAY 23-25, 2019 -- Helsinki, FINLANDen_US
dc.description.abstractBackground Radiotherapy (RT) involves the use of ionizing radiation in treating malignancies and benign disorders. However, RT damages target and healthy surrounding tissues in a dose-dependent manner. This effectively reduces patient compliance and quality of life, thereby warranting the prevention of RT-induced adverse effects on skin. Adipose-derived stem cells (ASCs) are used to treat RT-induced damage and platelet-rich plasma (PRP) provides a scaffold that potentiates the effects of ASCs. Thus, the aim of this study was to determine the mechanism employed by ASCs and PRP in protecting against RT-induced adverse effects. Methods We have established an immunodeficient mouse transplantation model using which human hair follicular units were implanted. When the follicular units were macroscopically and microscopically mature and anagenic, we administered localized RT. Subsequently, the mice were randomly divided into 4 groups based on the subcutaneous injection of the following to the irradiated transplantation site: saline, PRP, ASCs, and a combination of ASCs and PRP. Next, we used macroscopic and microscopic analyses to determine the protective effects of the injected solutions on skin and hair follicles. Results Adipose-derived stem cells reduced RT-induced adverse effects, such as impaired wound healing, alopecia, skin atrophy, and fibrosis by suppressing inflammation, dystrophy, degeneration, connective tissue synthesis, and apoptosis and increasing cellular proliferation, differentiation, and signaling. Moreover, these effects were augmented by PRP. Conclusions Thus, co-administering ASCs with PRP in mice prevented RT-induced adverse effects and can be tested for use in clinical practice.en_US
dc.description.sponsorshipEuropean Assoc Plast Surgen_US
dc.identifier.doi10.1097/SAP.0000000000002573
dc.identifier.endpage597en_US
dc.identifier.issn0148-7043
dc.identifier.issn1536-3708
dc.identifier.issue5en_US
dc.identifier.pmid33141771en_US
dc.identifier.scopus2-s2.0-85105827674en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage588en_US
dc.identifier.urihttps://doi.org/10.1097/SAP.0000000000002573
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13548
dc.identifier.volume86en_US
dc.identifier.wosWOS:000648538000019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnnals Of Plastic Surgeryen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdipose-Derived Stem Cellsen_US
dc.subjectAlopeciaen_US
dc.subjectPlatelet-Rich Plasmaen_US
dc.subjectRadiotherapyen_US
dc.subjectSkin Complicationsen_US
dc.titleEffects of Adipose-Derived Stem Cells and Platelet-Rich Plasma for Prevention of Alopecia and Other Skin Complications of Radiotherapyen_US
dc.typeConference Objecten_US

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