Impact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort study

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dc.contributor.authorOzturk, Savas
dc.contributor.authorTurgutalp, Kenan
dc.contributor.authorArici, Mustafa
dc.contributor.authorCetinkaya, Hakki
dc.contributor.authorAltiparmak, Mehmet Riza
dc.contributor.authorAydin, Zeki
dc.contributor.authorSoypacaci, Zeki
dc.date.accessioned2024-02-23T14:37:24Z
dc.date.available2024-02-23T14:37:24Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: Hospital-acquired acute kidney injury (HA-AKI) may commonly develop in Covid-19 patients and is expected to have higher mortality. There is little comparative data investigating the effect of HA-AKI on mortality of chronic kidney disease (CKD) patients and a control group of general population suffering from Covid-19. Materials and methods: HA-AKI development was assessed in a group of stage 3-5 CKD patients and control group without CKD among adult patients hospitalized for Covid-19. The role of AKI development on the outcome (in-hospital mortality and admission to the intensive care unit [ICU]) of patients with and without CKD was compared. Results: Among 621 hospitalized patients (age 60 [IQR: 47-73]), women: 44.1%), AKI developed in 32.5% of the patients, as stage 1 in 84.2%, stage 2 in 8.4%, and stage 3 in 7.4%. AKI developed in 48.0 % of CKD patients, whereas it developed in 17.6% of patients without CKD. CKD patients with HA-AKI had the highest mortality rate of 41.1% compared to 14.3% of patients with HA-AKI but no CKD (p < 0.001). However, patients with AKI+non-CKD had similar rates of ICU admission, mechanical ventilation, and death rate to patients with CKD without AKI. Adjusted mortality risks of the AKI+non-CKD group (HR: 9.0, 95% CI: 1.9-44.2) and AKI+CKD group (HR: 7.9, 95% CI: 1.9-33.3) were significantly higher than that of the non-AKI+non-CKD group. Conclusion: AKI frequently develops in hospitalized patients due to Covid-19 and is associated with high mortality. HA-AKI has worse outcomes whether it develops in patients with or without CKD, but the worst outcome was seen in AKI+CKD patients.en_US
dc.description.sponsorshipTurkish Society of Nephrology for the organizationen_US
dc.description.sponsorshipWe thank Turkish Society of Nephrology for the organization and funding of the study. We also would like to express our gratitude to the patients whose records were used in this study, without which this research would not be possible.en_US
dc.identifier.doi10.3906/sag-2011-169
dc.identifier.endpage961en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid33611868en_US
dc.identifier.scopus2-s2.0-85109970332en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage947en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2011-169
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16091
dc.identifier.volume51en_US
dc.identifier.wosWOS:000668244900008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectCovid-19en_US
dc.subjectHospitalizationen_US
dc.subjectMortalityen_US
dc.titleImpact of hospital-acquired acute kidney injury on Covid-19 outcomes in patients with and without chronic kidney disease: a multicenter retrospective cohort studyen_US
dc.typeArticleen_US

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