Evaluation of Serum Ischemia Modified Albumin Levels in Acute Rheumatic Fever Before and After Therapy

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dc.contributor.authorToker, Aysun
dc.contributor.authorKaratas, Zehra
dc.contributor.authorAltin, Hakan
dc.contributor.authorKaraarslan, Sevim
dc.contributor.authorCicekler, Humeyra
dc.contributor.authorAlp, Hayrullah
dc.date.accessioned2024-02-23T13:59:48Z
dc.date.available2024-02-23T13:59:48Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractTo investigate ischemia modified albumin (IMA) levels in children with acute rheumatic fever (ARF) before and after therapy and compare them with those of controls. Twenty seven patients with ARF and 18 healthy, age and sex matched children were included in the study. The diagnosis of ARF was established according to the modified Jones criteria. Follow-up studies were made when acute phase reactants [erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)] levels returned normal. IMA levels were measured using the rapid and colorimetric method with the albumin cobalt binding test. IMA levels were significantly higher in ARF group (p < 0.001) compared with controls at the time on admission. IMA (absorbance units) was measured as 0.41 +/- 0.10 in the control group, 0.55 (0.44-1.13) in the study group before treatment and 0.48 +/- 0.12 in the study group after treatment. After treatment, statistically important decrements were determined in the levels of ESR (p < 0.001), CRP (p < 0.001) and IMA (p < 0.01). There was no significant difference for IMA levels between after treatment and control group. IMA levels at the time on admission correlated positively with ESR (r = 0.605, p < 0.01) and CRP (r = 0.543, p < 0.01). The present study shows that increased serum IMA levels in patients with ARF at the time of diagnosis is a sign of increased inflammation. Thus, serum IMA levels may be used as a follow-up marker like CRP and ESR for evaluating the efficacy of treatment in ARF.en_US
dc.identifier.doi10.1007/s12098-013-1092-x
dc.identifier.endpage125en_US
dc.identifier.issn0019-5456
dc.identifier.issn0973-7693
dc.identifier.issue2en_US
dc.identifier.pmid23813149en_US
dc.identifier.scopus2-s2.0-84898546956en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://doi.org/10.1007/s12098-013-1092-x
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11334
dc.identifier.volume81en_US
dc.identifier.wosWOS:000331722500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAll India Inst Medical Sciencesen_US
dc.relation.ispartofIndian Journal Of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Rheumatic Feveren_US
dc.subjectIschemia Modified Albuminen_US
dc.subjectInflammationen_US
dc.subjectTreatmenten_US
dc.titleEvaluation of Serum Ischemia Modified Albumin Levels in Acute Rheumatic Fever Before and After Therapyen_US
dc.typeArticleen_US

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