Role of Neopterin in Determining the Efficacy of Interferon Therapy in Chronic Hepatitis B and C

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dc.contributor.authorOzcimen, Serap
dc.contributor.authorBitirgen, Mehmet
dc.contributor.authorKandemir, Bahar
dc.date.accessioned2024-02-23T14:29:55Z
dc.date.available2024-02-23T14:29:55Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractNeopterin (NP) is a pteridine derivative that is secreted as a response to gamma interferon stimulation. The purpose in this study was to investigate the relationship between the NP levels and the disease and determining the efficacy of an interferon (IFN) therapy in patients with chronic hepatitis B (CHB) and C (CHC). The study was conducted on 49 cases with CHB, 30 cases with CHC and 72 healthy individuals. Serum samples were taken from the patients receiving treatment at the beginning and at the end of the treatment and only once from the healthy individuals in the control group. The NP levels were found significantly higher in the patients with CHB and CHC than those in the control group. When the pre and post-treatment serum NP levels of the patients who received an interferon therapy were compared, the post-treatment NP levels of the patients who responded to the treatment were significantly higher. When a comparison was made before and after treatment, a decrease was seen in the NP levels in most of the infections due to decreased activation of the immune system. However, when the disease was treated with an IFN therapy, which is a treatment stimulating the immune system, the post-treatment NP level remained high.en_US
dc.identifier.doi10.15197/sabad.1.12.01
dc.identifier.endpage6en_US
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84926025327en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.15197/sabad.1.12.01
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14929
dc.identifier.volume12en_US
dc.identifier.wosWOS:000367540700001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherModestum Ltden_US
dc.relation.ispartofEuropean Journal Of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeopterinen_US
dc.subjectChronic Hepatitis Ben_US
dc.subjectChronic Hepatitis Cen_US
dc.titleRole of Neopterin in Determining the Efficacy of Interferon Therapy in Chronic Hepatitis B and Cen_US
dc.typeArticleen_US

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