The Effect of Combined Use of Platelet-Rich Plasma and Adipose-Derived Stem Cells on Fat Graft Survival

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dc.contributor.authorSeyhan, Nevra
dc.contributor.authorAlhan, Dogan
dc.contributor.authorUral, Ali Ugur
dc.contributor.authorGunal, Armagan
dc.contributor.authorAvunduk, Mustafa Cihad
dc.contributor.authorSavaci, Nedim
dc.date.accessioned2024-02-23T14:21:20Z
dc.date.available2024-02-23T14:21:20Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractBackground Free fat grafts have an unpredictable survival rate that limits their successful use. To increase the viability of fat grafts, it is important to minimize the reabsorption rate. Objective Our aim was to investigate whether the combined use of platelet-rich plasma (PRP) and adipose derived stem cells (ADSCs) would contribute an improvement in lower resorption rates of fat grafts. Methods Inbred Fischer 344 rats were randomized into 4 groups (n = 10). Fat grafts were mixed with Dulbecco modified Eagle medium in group A, with PRP in group B, with ADSC in group C, and with PRP + ADSC in group D and were injected to the scalp. In vitro growth factor (vascular endothelial growth factor, transforming growth factor-, and fibroblast growth factor) levels were compared using enzyme-linked immunoassay method. After 12 weeks weight, volume and histology of the transplants were evaluated. Results The mean weight and volume of the fat grafts were highest in group D. Histopathological investigations revealed that the number of viable adipocytes and blood vessels were highest in group D. The level of growth factors was significantly higher in stem cell plus PRP group. Conclusion Adipose-derived stem cells combined with PRP can enhance the survival of transplanted fat tissue.en_US
dc.identifier.doi10.1097/SAP.0000000000000480
dc.identifier.endpage620en_US
dc.identifier.issn0148-7043
dc.identifier.issn1536-3708
dc.identifier.issue5en_US
dc.identifier.pmid25710554en_US
dc.identifier.scopus2-s2.0-84942742136en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage615en_US
dc.identifier.urihttps://doi.org/10.1097/SAP.0000000000000480
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13547
dc.identifier.volume74en_US
dc.identifier.wosWOS:000353475100019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnnals Of Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPlatelet-Rich Plasmaen_US
dc.subjectAdipose-Derived Stem Cellsen_US
dc.subjectFat Graft Survivalen_US
dc.titleThe Effect of Combined Use of Platelet-Rich Plasma and Adipose-Derived Stem Cells on Fat Graft Survivalen_US
dc.typeArticleen_US

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