Relationship between nucleotide-binding oligomerization domain-containing protein 2 variants and severity of acute pancreatitis

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dc.contributor.authorHarputluoglu, M. M. M.
dc.contributor.authorOzbek, M.
dc.contributor.authorDemirel, U.
dc.contributor.authorOtlu, B.
dc.contributor.authorYener, O.
dc.contributor.authorGursoy, N. C.
dc.contributor.authorTikici, D.
dc.date.accessioned2024-02-23T14:49:15Z
dc.date.available2024-02-23T14:49:15Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractBackground and aim : Intestinal bat tier dysfunction has been implicated in the development of infectious complications of acute pancreatitis. Nucleotide-Binding Oligomerization Domain- Containing Protein 2 (NOD2) plays an important role in the proper functioning of intestinal defense mechanisms. Here, we investigated the frequency of NOD2 variants in patients with mild and severe acute pancreatitis. Materials and Methods : Groups 1, 2 and 3 comprised healthy participants and patients with mild and severe pancreatitis, respectively. Four NOD2 variants and serum interleukin-6 (IL-6), Tumor Necrosis Factor-a (TNF-a) and lipopolysaccharide-binding protein (LBP) levels were analyzed. Results: Three patients (3/32, 9.4%) in the severe pancreatitis group were positive for the p.R702W valiant. This valiant was negative in other groups. One, three and three patients in the healthy (1/27,3.7%), mild (3/36,8.3%) and severe pancreatitis (3/32, 9.4%) groups tested positive for the 1007fs variant, respectively. No significant difkrences in the frequencies of NOD2 variants were evident among the groups. Serum IL-6, TNF-a and IMP levels were markedly higher in the severe pancreatitis than the healthy and mild pancreatitis groups (all p<0.091). We observed no significant correlation between cytokine levels and NOD2 variants. Conclusion : Our results support an association between the presence of the p.R702W variant and severe pancreatitis.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [2015/95]en_US
dc.description.sponsorshipThis study was supported by Inonu University Scientific Research Projects Unit (Project number : 2015/95).en_US
dc.identifier.endpage290en_US
dc.identifier.issn1784-3227
dc.identifier.issue2en_US
dc.identifier.pmid31314190en_US
dc.identifier.scopus2-s2.0-85068891161en_US
dc.identifier.startpage285en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/18074
dc.identifier.volume82en_US
dc.identifier.wosWOS:000474250900008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Catholique Louvain-Uclen_US
dc.relation.ispartofActa Gastro-Enterologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMucosal Immunityen_US
dc.subjectInflammationen_US
dc.subjectCytokinesen_US
dc.subjectAcute Pancreatitisen_US
dc.titleRelationship between nucleotide-binding oligomerization domain-containing protein 2 variants and severity of acute pancreatitisen_US
dc.typeArticleen_US

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