Total antioxidant and total oxidant states, and serum paraoxonase-1 in neonatal sepsis

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dc.contributor.authorAnnagur, Ali
dc.contributor.authorOrs, Rahmi
dc.contributor.authorAltunhan, Huseyin
dc.contributor.authorKurban, Sevil
dc.contributor.authorErtugrul, Sabahattin
dc.contributor.authorKonak, Murat
dc.contributor.authorUygun, Saime Sunduz
dc.date.accessioned2024-02-23T14:24:35Z
dc.date.available2024-02-23T14:24:35Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractBackgroundParaoxonase-1 (PON-1) is an enzyme with a glycoprotein structure that depends on calcium and which is located in serum high-density lipoprotein (HDL). The aim of this study was to evaluate PON-1, and oxidant/antioxidant state, before and after treatment for neonatal sepsis, and to determine the usability of PON-1 in neonatal sepsis treatment. MethodsA total of 35 neonatal sepsis patients and 35 healthy controls were included in the study. Activity of PON-1, total oxidant state (TOS) and total antioxidant state (TAS) were measured and oxidative stress index (OSI) was calculated. ResultsIn the neonatal sepsis patients, pre-treatment TAS, TOS and OSI were significantly higher than the post-treatment levels (P < 0.0001, P < 0.0001 and P < 0.0001, respectively), and PON-1 was significantly lower (P < 0.0001). Similarly, pre-treatment TAS, TOS and OSI in the sepsis group were also significantly higher than in the control group (P < 0.0001, P < 0.0001 and P < 0.0001, respectively) and PON-1 was significantly lower (P < 0.0001). Post-treatment TAS in the sepsis group was significantly higher than in the control group (P = 0.009), whereas post-treatment TOS, OSI and PON-1 in the sepsis group were not significantly different to the control group (P = 0.078, P = 0.597 and P = 0.086, respectively). ConclusionLow serum PON-1 was found in neonatal sepsis. Serum PON-1 is thought to be a useful biomarker to evaluate the effectiveness of treatment and recovery in neonatal sepsis.en_US
dc.identifier.doi10.1111/ped.12557
dc.identifier.endpage613en_US
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue4en_US
dc.identifier.pmid25488411en_US
dc.identifier.scopus2-s2.0-84940475437en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage608en_US
dc.identifier.urihttps://doi.org/10.1111/ped.12557
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14023
dc.identifier.volume57en_US
dc.identifier.wosWOS:000360501500017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatrics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeonatal Sepsisen_US
dc.subjectOxidative Stress Indexen_US
dc.subjectParaoxonase-1en_US
dc.subjectTotal Antioxidant Stateen_US
dc.subjectTotal Oxidant Stateen_US
dc.titleTotal antioxidant and total oxidant states, and serum paraoxonase-1 in neonatal sepsisen_US
dc.typeArticleen_US

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